A Convenient Synthesis of New Pyrazolo[4,3-d]pyrimidines and Their Fused Heterocycles

被引：12
|
作者：
Rote, Ramhari V. [1 ]
Shelar, Deepak P. [1 ]
Patil, Sandeep R. [1 ]
Jachak, Madhukar N. [1 ]
机构：
[1] Univ Pune, KTHM Coll, Organ Chem Res Ctr, Dept Chem, Nasik 422002, Maharashtra, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 03期
关键词：
POTENTIAL PURINE ANTAGONISTS; ADENOSINE RECEPTOR ANTAGONISTS; PYRAZOLO-TRIAZOLO-PYRIMIDINE; CROSS-COUPLING REACTION; PYRAZOLO<3,4-D>PYRIMIDINES; 1-ALKENYLBORANES; DERIVATIVES;
D O I：
10.1002/jhet.2006
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of some fused heterocycles originated from pyrazolopyrimidines were synthesized using 4-amino1-methyl-3-propyl-1H-pyrazole-5-carboxamide as a starting material. The nucleophilic substitution reactions with different amino acids followed by cyclization and Suzuki-Miyaura cross-coupling reactions with different aryl boronic acids of 7-chloro-5-(4-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine were performed. Also, the oxidative cyclization reactions of 1-(5-(4-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)hydrazine with different aldehydes in the presence of diacetoxy iodobenzene are described. All the synthesized compounds were characterized by analytical and spectroscopic methods.
引用
收藏
页码：815 / 823
页数：9
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