Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents

被引:197
作者
Barreca, ML
Balzarini, J
Chimirri, A
De Clercq, E
De Luca, L
Höltje, HD
Höltje, M
Monforte, AM
Monforte, P
Pannecouque, C
Rao, A
Zappalà, M
机构
[1] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy
[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
[3] Univ Dusseldorf, Inst Pharmaceut Chem, D-4000 Dusseldorf, Germany
关键词
D O I
10.1021/jm020977+
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Starting from 1H,3H-thiazolo[3,4-albenzimidazoles (TBZs), we performed the design, synthesis, and the structure-activity relationship studies of a series of 2,3-diaryl-1,3-thiazolidin-4-ones. Some derivatives proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentrations with minimal cytotoxicity, thereby acting as nonnucleoside HIV-1 RT inhibitors (NNRTIs). Computational studies were used to delineate the ligand-RT interactions and to probe the binding of the ligands to HIV-1 RT.
引用
收藏
页码:5410 / 5413
页数:4
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