Follow-up study of a patient with early onset cerebral amyloid angiopathy following childhood cadaveric dural graft

被引：12

作者：

Yoshiki, Kenji ^{[1
,2
]}

Hirose, Genjiro ^{[3
]}

Kumahashi, Kazuhiko ^{[1
]}

Kohda, Yukihiko ^{[1
]}

Ido, Kazunori ^{[4
]}

Shioya, Akihiro ^{[5
]}

Misaki, Kouichi ^{[2
]}

Kasuga, Kensaku ^{[6
]}

机构：

[1] Asanogawa Gen Hosp, Dept Neurosurg, Kanazawa, Ishikawa, Japan

[2] Kanazawa Univ, Grad Sch Med Sci, Dept Neurosurg, Kanazawa, Ishikawa, Japan

[3] Asanogawa Gen Hosp, Dept Neurol, Naka 83,Kosaka Machi, Kanazawa, Ishikawa 9208621, Japan

[4] Asanogawa Gen Hosp, Dept Rehabil Med, Kanazawa, Ishikawa, Japan

[5] Kanazawa Med Univ, Dept Pathol & Lab Med, Kanazawa, Ishikawa, Japan

[6] Niigata Univ, Brain Res Inst, Dept Mol Genet, Niigata, Japan

来源：

ACTA NEUROCHIRURGICA | 2021年 / 163卷 / 05期

关键词：

Cadaveric dural graft; Cerebral amyloid angiopathy; Multiple microbleeds; Prion-like transmission; T2*image;

D O I：

10.1007/s00701-021-04751-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We retrospectively studied the T2 star (T2*)-weighted magnetic resonance imaging (MRI) of a 40-year-old patient diagnosed with symptomatic early-onset cerebral amyloid angiopathy (CAA), occurring 34 years following childhood neurosurgery using a cadaveric dural patch. Our findings revealed that CAA associated with cadaveric dural transplantation could progress rapidly, sometimes with bilateral bleeding. This microbleed evolution is suggestive of water-soluble amyloid-beta transmission via cerebrospinal fluid alongside perivascular drainage pathways with deposition in the cerebral artery walls due to clearance disturbances. Multiple intracerebral hemorrhages associated with CAA with a childhood cadaveric dural graft should be considered a life-threatening medical complication.

引用

页码：1451 / 1455

页数：5