A Short, Economical Synthesis of 2-Methoxyestradiol, an Anticancer Agent in Clinical Trials

被引：24

作者：

Hou, Yuqing ^{[1
,2
]}

Meyers, Cal Y. ^{[1
,2
]}

Akomeah, Mercy ^{[3
]}

机构：

[1] So Illinois Univ, Meyers Inst Interdisciplinary Res Organ & Med Che, Carbondale, IL 62901 USA

[2] So Illinois Univ, Dept Chem & Biochem, Carbondale, IL 62901 USA

[3] Summer Undergrad Res Wartburg Coll, Waverly, IA 50677 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 16期

关键词：

INHIBITS TUBULIN POLYMERIZATION; COLCHICINE BINDING-SITE; GRIGNARD-REAGENTS; ANTIMITOTIC ACTIVITY; ORGANIC PEROXIDES; DRUG CANDIDATE; METABOLITE; ESTRADIOL; ORGANOLITHIUM; ANALOGS;

D O I：

10.1021/jo901086s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Methoxyestradiol, a natural metabolite of estradiol and potential therapeutic agent for many types of cancers, has been synthesized successfully in three steps, starting from estradiol and cumyl methyl peroxide.

引用

页码：6362 / 6364

页数：3

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