Demyelinating diseases

The most common central nervous system demyelinating disease which adult neurologists have to deal with is multiple sclerosis (MS). It has a prevalence of about 1 per 1000 in white populations in temperate climates, occurs most commonly in young adults, and is a particularly common cause of locomotor disability in this age group. There has been a major increase in clinical research studies in MS in recent years, and the beginnings of progress in the development of disease modifying therapy. In this section, four out of the five reviews are devoted to different aspects of the recent literature concerning MS.