机构:
St Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USA
Chauhan, Anil K.
[1
]
Moore, Terry L.
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USA
Moore, Terry L.
[1
]
Bi, Ye
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USA
Bi, Ye
[1
]
Chen, Chen
论文数: 0引用数: 0
h-index: 0
机构:
St Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USASt Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USA
Chen, Chen
[1
]
机构:
[1] St Louis Univ, Sch Med, Div Adult & Pediat Rheumatol, 1402 South Grand Blvd, St Louis, MO 63104 USA
CD4(+) T-cells in systemic lupus erythematosus (SLE) patients show altered T-cell receptor signaling, which utilizes Fc-receptor gamma-chain FcR gamma-Syk. A role for Fc gamma RIIIa activation from immune complex (IC) ligation and sublytic terminal complement complex (C5b-9) in CD4(+) T-cell responses is not investigated. In this study, we show that the ICs present in SLE patients by ligating to Fc gamma RIIIa on CD4(+) T-cells phosphorylate Syk and provide a co-stimulatory signal to CD4(+) T-cells in the absence of CD28 signal. This led to the development of pathogenic IL-17A(+) and IFN-gamma(high) CD4(+) T-cells in vitro. Cytokines IL-1 beta, IL-6, TGF-beta 1, and IL-23 were the only requirement for the development of both populations. SLE patients CD4(+) T-cells that expressed CD25, CD69, and CD98 bound to ICs showed pSyk and produced IFN-gamma and IL-17A. This Fc gamma RIIIa-mediated co-signal differentially up-regulated the expression of IFN pathway genes compared with CD28 co-signal. Fc gamma RIIIa-pSyk upregulated several toll-like receptor genes as well as the HMGB1 and MyD88 gene transcripts. ICs co-localized with these toll-like receptor pathway proteins. These results suggest a role for the Fc gamma RIIIa-pSyk signal in modulating adaptive immune responses.
机构:
Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
Amarilyo, Gil
Lourenco, Elaine V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
Lourenco, Elaine V.
Shi, Fu-Dong
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Div Neurol, Phoenix, AZ 85013 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
Shi, Fu-Dong
La Cava, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
机构:Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Barton, GM
Kagan, JC
论文数: 0引用数: 0
h-index: 0
机构:Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Kagan, JC
Medzhitov, R
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Cai, Gang
Nie, Xiaomeng
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Dept Resp Dis, Changhai Hosp, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Nie, Xiaomeng
Zhang, Weiwei
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Expt Diag, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Zhang, Weiwei
Wu, Beiying
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Wu, Beiying
Lin, Jiafei
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Lin, Jiafei
Wang, Huaizhou
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Expt Diag, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Wang, Huaizhou
Jiang, Cen
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Jiang, Cen
Shen, Qian
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Expt Diag, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
机构:
Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
Amarilyo, Gil
Lourenco, Elaine V.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
Lourenco, Elaine V.
Shi, Fu-Dong
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Barrow Neurol Inst, Div Neurol, Phoenix, AZ 85013 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
Shi, Fu-Dong
La Cava, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
机构:Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Barton, GM
Kagan, JC
论文数: 0引用数: 0
h-index: 0
机构:Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
Kagan, JC
Medzhitov, R
论文数: 0引用数: 0
h-index: 0
机构:
Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USAYale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Cai, Gang
Nie, Xiaomeng
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Dept Resp Dis, Changhai Hosp, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Nie, Xiaomeng
Zhang, Weiwei
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Expt Diag, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Zhang, Weiwei
Wu, Beiying
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Wu, Beiying
Lin, Jiafei
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Lin, Jiafei
Wang, Huaizhou
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Expt Diag, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Wang, Huaizhou
Jiang, Cen
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China
Jiang, Cen
Shen, Qian
论文数: 0引用数: 0
h-index: 0
机构:
Second Mil Med Univ, Changhai Hosp, Dept Expt Diag, Shanghai 200433, Peoples R ChinaShanghai Jiao Tong Univ, Dept Lab Med, Sch Med, Shanghai 200025, Peoples R China