Exosome complex and pervasive transcription in eukaryotic genomes

被引：38

作者：

Belostotsky, Dmitry ^{[1
]}

机构：

[1] Univ Missouri, Sch Biol Sci, Kansas City, MO 64110 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2009年 / 21卷 / 03期

关键词：

QUALITY-CONTROL; BIDIRECTIONAL PROMOTERS; RNA DEGRADATION; NUCLEAR EXOSOME; GENE; TERMINATION; SUBUNIT; CONTRIBUTE; TURNOVER; PREVENTS;

D O I：

10.1016/j.ceb.2009.04.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosome complex is widely conserved, functionally versatile, and essential constituent of the machinery regulating gene expression in the nucleus as well as in the cytoplasm. While the most fundamental enzymatic property of exosome is ribonucleolytic activity, its in vivo functions are varied, highly specific, and tightly regulated, and include RNA degradation, processing, and quality control. Recent reports reveal that exosome also has a prominent role in gene silencing as well as in regulating the expression of a wide variety of noncoding RNAs. Taken together with the emerging notion of pervasive genomewide transcription, these findings indicate that 'policing the transcriptome' may well turn out to be the major role of exosome in eukaryotes.

引用

页码：352 / 358

页数：7

共 47 条

[1] Regulation of yeast NRD1 expression by premature transcription termination [J].

Arigo, JT ;

Carroll, KL ;

Ames, JM ;

Corden, JL .

MOLECULAR CELL, 2006, 21 (05) :641-651

[2] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[3] TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway [J].

Buehler, Marc ;

Spies, Noah ;

Bartel, David P. ;

Moazed, Danesh .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (10) :1015-1023

[4] RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing [J].

Buehler, Marc ;

Haas, Wilhelm ;

Gygi, Steven P. ;

Moazed, Danesh .

CELL, 2007, 129 (04) :707-721

[5] Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p [J].

Callahan, Kevin P. ;

Butler, J. Scott .

NUCLEIC ACIDS RESEARCH, 2008, 36 (21) :6645-6655

[6] Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in s.: cerevisiae [J].

Camblong, Jurgi ;

Iglesias, Nahid ;

Fickentscher, Céline ;

Dieppois, Guennaelle ;

Stutz, Françoise .

CELL, 2007, 131 (04) :706-717

[7] The transcriptional landscape of the mammalian genome [J].

Carninci, P ;

Kasukawa, T ;

Katayama, S ;

Gough, J ;

Frith, MC ;

Maeda, N ;

Oyama, R ;

Ravasi, T ;

Lenhard, B ;

Wells, C ;

Kodzius, R ;

Shimokawa, K ;

Bajic, VB ;

Brenner, SE ;

Batalov, S ;

Forrest, ARR ;

Zavolan, M ;

Davis, MJ ;

Wilming, LG ;

Aidinis, V ;

Allen, JE ;

Ambesi-Impiombato, X ;

Apweiler, R ;

Aturaliya, RN ;

Bailey, TL ;

Bansal, M ;

Baxter, L ;

Beisel, KW ;

Bersano, T ;

Bono, H ;

Chalk, AM ;

Chiu, KP ;

Choudhary, V ;

Christoffels, A ;

Clutterbuck, DR ;

Crowe, ML ;

Dalla, E ;

Dalrymple, BP ;

de Bono, B ;

Della Gatta, G ;

di Bernardo, D ;

Down, T ;

Engstrom, P ;

Fagiolini, M ;

Faulkner, G ;

Fletcher, CF ;

Fukushima, T ;

Furuno, M ;

Futaki, S ;

Gariboldi, M .

SCIENCE, 2005, 309 (5740) :1559-1563

[8] Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells [J].

Chekanova, JA ;

Shaw, RJ ;

Wills, MA ;

Belostotsky, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (42) :33158-33166

[9] Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome [J].

Chekanova, Julia A. ;

Gregory, Brian D. ;

Reverdatto, Sergei V. ;

Chen, Huaming ;

Kumar, Ravi ;

Hooker, Tanya ;

Yazaki, Junshi ;

Li, Pinghua ;

Skiba, Nikolai ;

Peng, Qian ;

Alonso, Jose ;

Brukhin, Vladimir ;

Grossniklaus, Ueli ;

Ecker, Joseph R. ;

Belostotsky, Dmitry A. .

CELL, 2007, 131 (07) :1340-1353

[10] Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae [J].

Davis, CA ;

Ares, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3262-3267

← 1 2 3 4 5 →