BAP1 in solid tumors

被引：20
|
作者：
Di Nunno, Vincenzo [1 ]
Frega, Giorgio [2 ]
Santoni, Matteo [3 ]
Gatto, Lidia [2 ]
Fiorentino, Michelangelo [4 ]
Montironi, Rodolfo [5 ]
Battelli, Nicola [3 ]
Brandi, Giovanni [2 ]
Massari, Francesco [1 ]
机构：
[1] St Orsola Marcello Malpighi Hosp, Div Oncol, Bologna, Italy
[2] Univ Bologna, St Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, Oncol Unit, Bologna, Italy
[3] Macerata Hosp, Dept Oncol, Macerata, Italy
[4] St Orsola Marcello Malpighi Hosp, Addarii Inst Oncol, Pathol Serv, Bologna, Italy
[5] Polytech Univ Marche Reg, Sch Med, Sect Pathol Anat, United Hosp, Ancona, Italy
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 18期
关键词：
BAP1; cholangiocarcinoma; melanoma; mesothelioma; renal cell carcinoma; thymic carcinoma; HISTONE DEACETYLASE INHIBITOR; RENAL-CELL CARCINOMA; BRCA1-ASSOCIATED PROTEIN-1; INTRAHEPATIC CHOLANGIOCARCINOMA; MUTATIONS PREDISPOSE; PHASE-II; MESOTHELIOMA; ASBESTOS; CANCER; DIAGNOSIS;
D O I：
10.2217/fon-2018-0915
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
One of the most attractive cancer-related genes under investigation is BAP1. Reasons of this growing interest are related to the wide spectrum of pathways directly or indirectly modulated by this gene and shared by several solid tumors. Programmed cell-death, cell metabolisms, immune cells development, ferroptosis and defects in DNA damage response are only some of the multitude of processes depending on BAP1. Loss of this gene seems to occur in different times of tumor history. Moreover, times of BAP1 loss strongly diverge among primary tumors suggesting the presence of several and different triggering factors. Regardless of when it happens, BAP1 loss usually results in prognosis worsening and in the acquisition of more aggressive clinical features by cancer cells.
引用
收藏
页码：2151 / 2162
页数：12
相关论文
共 50 条
  • [41] Inherited predisposition to malignant mesothelioma: germline BAP1 mutations and beyond
    Pagliuca, F.
    Marino, F. Zito
    Morgillo, F.
    Della Corte, C.
    Santini, M.
    Vicidomini, G.
    Guggino, G.
    De Dominicis, G.
    Campione, S.
    Accardo, M.
    Cozzolino, I
    Franco, R.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2021, 25 (12) : 4236 - 4246
  • [42] Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations
    Kadariya, Yuwaraj
    Cheung, Mitchell
    Xu, Jinfei
    Pei, Jianming
    Sementino, Eleonora
    Menges, Craig W.
    Cai, Kathy Q.
    Rauscher, Frank J.
    Klein-Szanto, Andres J.
    Testa, Joseph R.
    CANCER RESEARCH, 2016, 76 (09) : 2836 - 2844
  • [43] BAP1 expression in cutaneous melanoma: a pilot study
    Murali, Rajmohan
    Wilmott, James S.
    Jakrot, Valerie
    Al-Ahmadie, Hikmat A.
    Wiesner, Thomas
    McCarthy, Stanley W.
    Thompson, John F.
    Scolyer, Richard A.
    PATHOLOGY, 2013, 45 (06) : 606 - 609
  • [44] Expanded detection and impact of BAP1 alterations in cancer
    Sturgill, Ian R.
    Raab, Jesse R.
    Hoadley, Katherine A.
    NAR CANCER, 2024, 6 (04):
  • [45] Roles of the BAP1 Tumor Suppressor in Cell Metabolism
    Han, Anna
    Purwin, Timothy J.
    Aplin, Andrew E.
    CANCER RESEARCH, 2021, 81 (11) : 2807 - 2814
  • [46] A mechanism for the tissue specificity in BAP1 cancer syndrome
    Machida, Yuichi J.
    TRANSLATIONAL CANCER RESEARCH, 2019, 8 : S621 - S624
  • [47] BAP1 regulates different mechanisms of cell death
    Affar, El Bachir
    Carbone, Michele
    CELL DEATH & DISEASE, 2018, 9
  • [48] Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and PBRM1 expression, and demonstrates specific clinicopathological and genetic characteristics with BAP1 loss
    Misumi, Kento
    Hayashi, Akimasa
    Shibahara, Junji
    Arita, Junichi
    Sakamoto, Yoshihiro
    Hasegawa, Kiyoshi
    Kokudo, Norihiro
    Fukayama, Masashi
    HISTOPATHOLOGY, 2017, 70 (05) : 766 - 774
  • [49] Immunohistochemical Assessment of BAP1 Protein in Mucoepidermoid Carcinomas
    Kakkar, Aanchal
    Guleria, Prerna
    Madan, Karan
    Kumar, Rajeev
    Kumar, Sunil
    Jain, Deepali
    INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, 2019, 71 (01) : 33 - 37
  • [50] BAP1 mutations in uveal melanoma
    Koopmans, Anna
    Verdijk, Robert
    van den Bosch, Thierry
    van den Berg, Mike
    Vaarwater, Jolanda
    Paridaens, Dion
    Kilic, Emine
    de Klein, Annelies
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
12345