BAP1 in solid tumors

被引：20

作者：

Di Nunno, Vincenzo ^{[1
]}

Frega, Giorgio ^{[2
]}

Santoni, Matteo ^{[3
]}

Gatto, Lidia ^{[2
]}

Fiorentino, Michelangelo ^{[4
]}

Montironi, Rodolfo ^{[5
]}

Battelli, Nicola ^{[3
]}

Brandi, Giovanni ^{[2
]}

Massari, Francesco ^{[1
]}

机构：

[1] St Orsola Marcello Malpighi Hosp, Div Oncol, Bologna, Italy

[2] Univ Bologna, St Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, Oncol Unit, Bologna, Italy

[3] Macerata Hosp, Dept Oncol, Macerata, Italy

[4] St Orsola Marcello Malpighi Hosp, Addarii Inst Oncol, Pathol Serv, Bologna, Italy

[5] Polytech Univ Marche Reg, Sch Med, Sect Pathol Anat, United Hosp, Ancona, Italy

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 18期

关键词：

BAP1; cholangiocarcinoma; melanoma; mesothelioma; renal cell carcinoma; thymic carcinoma; HISTONE DEACETYLASE INHIBITOR; RENAL-CELL CARCINOMA; BRCA1-ASSOCIATED PROTEIN-1; INTRAHEPATIC CHOLANGIOCARCINOMA; MUTATIONS PREDISPOSE; PHASE-II; MESOTHELIOMA; ASBESTOS; CANCER; DIAGNOSIS;

D O I：

10.2217/fon-2018-0915

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the most attractive cancer-related genes under investigation is BAP1. Reasons of this growing interest are related to the wide spectrum of pathways directly or indirectly modulated by this gene and shared by several solid tumors. Programmed cell-death, cell metabolisms, immune cells development, ferroptosis and defects in DNA damage response are only some of the multitude of processes depending on BAP1. Loss of this gene seems to occur in different times of tumor history. Moreover, times of BAP1 loss strongly diverge among primary tumors suggesting the presence of several and different triggering factors. Regardless of when it happens, BAP1 loss usually results in prognosis worsening and in the acquisition of more aggressive clinical features by cancer cells.

引用

页码：2151 / 2162

页数：12

共 50 条

[31] BAP1 Inactivation in Mesothelioma Is Highly Prevalent
Zauderer, Marjorie
Cercek, Andrea
Rimner, Andreas
Rusch, Valerie
Adusumilli, Prasad S.
Nash, Garrett M.
Moreira, Andre
Hmeljak, Julija
Ladanyi, Marc
Krug, Lee M.
JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) : S402 - S402
[32] Mesothelioma in a Setting of Germline BAP1 Mutations
Carbone, Michele
Pass, Harvey
Yang, Haining
JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S61 - S61
[33] Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases
Rai, K.
Pilarski, R.
Cebulla, C. M.
Abdel-Rahman, M. H.
CLINICAL GENETICS, 2016, 89 (03) : 285 - 294
[34] BAP1 is a novel regulator of HIF-1α
Bononi, Angela
Wang, Qian
Zolondick, Alicia A.
Bai, Fang
Steele-Tanji, Mika
Suarez, Joelle S.
Pastorino, Sandra
Sipes, Abigail
Signorato, Valentina
Ferro, Angelica
Novelli, Flavia
Kim, Jin-Hee
Minaai, Michael
Takinishi, Yasutaka
Pellegrini, Laura
Napolitano, Andrea
Xu, Ronghui
Farrar, Christine
Goparaju, Chandra
Bassi, Cristian
Negrini, Massimo
Pagano, Ian
Sakamoto, Greg
Gaudino, Giovanni
Pass, Harvey I.
Onuchic, Jose N.
Yang, Haining
Carbone, Michele
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (04)
[35] Targeting BAP1: a new paradigm for mesothelioma
Schunselaar, L. M.
Zwart, W.
Baas, P.
LUNG CANCER, 2017, 109 : 145 - 146
[36] Comparative genetics of diffuse malignant mesothelioma tumors of the peritoneum and pleura, with focus on BAP1 expression
Brevet, Marie
PLEURA AND PERITONEUM, 2016, 1 (02) : 91 - 97
[37] Loss of BAP1 in Pheochromocytomas and Paragangliomas Seems Unrelated to Genetic Mutations
Maffeis, Valeria
Cappellesso, Rocco
Nicole, Lorenzo
Guzzardo, Vincenza
Menin, Chiara
Elefanti, Lisa
Schiavi, Francesca
Guido, Maria
Fassina, Ambrogio
ENDOCRINE PATHOLOGY, 2019, 30 (04) : 276 - 284
[38] Loss of BAP1 Expression Occurs Rarely to Never in Colorectal Adenocarcinoma
Chui, Jeanie
Verdonk, Brandon
Gill, Anthony J.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2018, 26 (09) : e91 - e92
[39] Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma
Sneddon, Sophie
Leon, Justine S.
Dick, Ian M.
Cadby, Gemma
Olsen, Nola
Brims, Fraser
Allcock, Richard J. N.
Moses, Eric K.
Melton, Phillip E.
de Klerk, Nicholas
Musk, A. W.
Robinson, Bruce W. S.
Creaney, Jenette
GENE, 2015, 563 (01) : 103 - 105
[40] Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide
Walpole, Sebastian
Pritchard, Antonia L.
Cebulla, Colleen M.
Pilarski, Robert
Stautberg, Meredith
Davidorf, Frederick H.
de la Fouchardiere, Arnaud
Cabaret, Odile
Golmard, Lisa
Stoppa-Lyonnet, Dominique
Garfield, Erin
Njauw, Ching-Ni
Cheung, Mitchell
Turunen, Joni A.
Repo, Pauliina
Jarvinen, Reetta-Stiina
van Doorn, Remco
Jager, Martine J.
Luyten, Gregorius P. M.
Marinkovic, Marina
Chau, Cindy
Potrony, Miriam
Hoiom, Veronica
Helgadottir, Hildur
Pastorino, Lorenza
Bruno, William
Andreotti, Virginia
Dalmasso, Bruna
Ciccarese, Giulia
Queirolo, Paola
Mastracci, Luca
Wadt, Karin
Kiilgaard, Jens Folke
Speicher, Michael R.
van Poppelen, Natasha
Kilic, Emine
Al-Jamal, Rana'a T.
Dianzani, Irma
Betti, Marta
Bergmann, Carsten
Santagata, Sandro
Dahiya, Sonika
Taibjee, Saleem
Burke, Jo
Poplawski, Nicola
O'Shea, Sally J.
Newton-Bishop, Julia
Adlard, Julian
Adams, David J.
Lane, Anne-Marie
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2018, 110 (12): : 1328 - 1341

← 1 2 3 4 5 →