Staphylococcus epidermidis - the 'accidental' pathogen

被引：1275

作者：

Otto, Michael ^{[1
]}

机构：

[1] NIAID, NIH, 9000 Rockville Pike Bldg,33 1W10, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 08期

关键词：

POLYSACCHARIDE INTERCELLULAR ADHESIN; COAGULASE-NEGATIVE STAPHYLOCOCCI; QUORUM-SENSING SYSTEM; CATHETER-ASSOCIATED INFECTION; FIBRINOGEN-BINDING PROTEIN; CASSETTE CHROMOSOME MEC; FOREIGN-BODY INFECTION; BIOFILM FORMATION; MOLECULAR-CLONING; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS;

D O I：

10.1038/nrmicro2182

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host. Accordingly, S. epidermidis does not produce aggressive virulence determinants. Rather, factors that normally sustain the commensal lifestyle of S. epidermidis seem to give rise to additional benefits during infection. Furthermore, we are beginning to comprehend the roles of S. epidermidis in balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles of S. epidermidis.

引用

页码：555 / 567

页数：13

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