Effect of Platelet-Rich Plasma on Intervertebral Disc Degeneration In Vivo and In Vitro: A Critical Review

被引：31
作者：
Chang, Yvang [1 ,2 ]
Yang, Ming [1 ,2 ]
Ke, Song [1 ,2 ]
Zhang, Yu [1 ,2 ]
Xu, Gang [1 ,2 ]
Li, Zhonghai [1 ,2 ]
机构：
[1] Dalian Med Univ, Affiliated Hosp 1, Dept Orthopaed, Dalian, Peoples R China
[2] Key Lab Mol Mech Repair & Remodeling Orthopaed Di, Dalian, Liaoning, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷
关键词：
LOW-BACK-PAIN; PROLIFERATION; CELLS;
D O I：
10.1155/2020/8893819
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Intervertebral disc degeneration (IDD) is a globally occurring disease that represents a significant cause of socioeconomic problems. Currently, the main method for treating IDD is surgery, including discectomy and vertebral fusion. Several in vitro experiments demonstrated that platelet-rich plasma (PRP) could stimulate cell proliferation and extracellular matrix regeneration. Additionally, in vivo experiments have proven that PRP injection could restore intervertebral disc height. Clinical studies demonstrated that PRP injection could significantly relieve patient pain. However, further studies are still required to clarify the roles of PRP in IDD prevention and treatment. This review is aimed at summarizing and critically analyzing the current evidence regarding IDD treatment with PRP.
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页数：10
相关论文
共 48 条
[1]   Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis [J].
Akeda, K. ;
An, H. S. ;
Okuma, M. ;
Attawia, M. ;
Miyamoto, K. ;
Thonar, E. J-M. A. ;
Lenz, M. E. ;
Sah, R. L. ;
Masuda, K. .
OSTEOARTHRITIS AND CARTILAGE, 2006, 14 (12) :1272-1280
[2]   Platelet-rich plasma in the management of chronic low back pain: a critical review [J].
Akeda, Koji ;
Yamada, Junichi ;
Linn, Erikka T. ;
Sudo, Akihiro ;
Masuda, Koichi .
JOURNAL OF PAIN RESEARCH, 2019, 12 :753-767
[3]  
Akeda K, 2017, ASIAN SPINE J, V11, P380, DOI 10.4184/asj.2017.11.3.380
[4]  
Ammar Ahmed Sabry, 2017, Asian J Neurosurg, V12, P681, DOI 10.4103/ajns.AJNS_351_16
[5]   The Contribution of Adipose Tissue-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma to the Treatment of Chronic Equine Laminitis: A Proof of Concept [J].
Angelone, Mario ;
Conti, Virna ;
Biacca, Cristiano ;
Battaglia, Beatrice ;
Pecorari, Laura ;
Piana, Francesco ;
Gnudi, Giacomo ;
Leonardi, Fabio ;
Ramoni, Roberto ;
Basini, Giuseppina ;
Dotti, Silvia ;
Renzi, Sabrina ;
Ferrari, Maura ;
Grolli, Stefano .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (10)
[6]   Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells [J].
Bai, Zhibiao ;
Liu, Wei ;
He, Danshuang ;
Wang, Yiyang ;
Yi, Weiwei ;
Luo, Changqi ;
Shen, Jieliang ;
Hu, Zhenming .
AGING-US, 2020, 12 (08) :7534-7548
[7]   Efficacy of Platelet Rich Plasma via Lumbar Epidural Route in Chronic Prolapsed Intervertebral Disc Patients-A Pilot Study [J].
Bhatia, Rohan ;
Chopra, Gaurav .
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016, 10 (09) :UC5-UC7
[8]  
Bodor M., 2014, PLATELET RICH PLASMA, P265
[9]   Tissue-engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF-β1 in platelet-rich plasma [J].
Chen, Wei-Hong ;
Lo, Wen-Cheng ;
Lee, Jie-Jen ;
Su, Ching-Hua ;
Lin, Che-Tong ;
Liu, Hen-Yu ;
Lin, Tsou-Wen ;
Lin, Wei-Chao ;
Huang, Te-Yang ;
Deng, Win-Ping .
JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 209 (03) :744-754
[10]   Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma [J].
Chen, Wei-Hong ;
Liu, Hen-Yu ;
Lo, Wen-Cheng ;
Wu, Shinn-Chih ;
Chi, Chau-Hwa ;
Chang, Hsueh-Yuan ;
Hsiao, Shih-Hsiang ;
Wu, Chih-Hsiung ;
Chiu, Wen-Ta ;
Chen, Bao-Ji ;
Deng, Win-Ping .
BIOMATERIALS, 2009, 30 (29) :5523-5533
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