Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape

被引：150

作者：

Gajjar, Amar ^{[1
]}

Bowers, Daniel C. ^{[2
]}

Karajannis, Matthias A. ^{[3
,4
]}

Leary, Sarah ^{[5
,6
]}

Witt, Hendrik ^{[7
,8
]}

Gottardo, Nicholas G. ^{[9
,10
]}

机构：

[1] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[2] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[3] NYU, Perlmutter Canc Ctr, New York, NY USA

[4] NYU, Langone Med Ctr, New York, NY USA

[5] Univ Washington, Sch Med, Seattle, WA USA

[6] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[7] German Canc Res Ctr, Heidelberg, Germany

[8] Heidelberg Univ, Heidelberg, Germany

[9] Princess Margaret Hosp Children, Perth, WA, Australia

[10] Univ Western Australia, Perth, WA 6009, Australia

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 33卷 / 27期

关键词：

CENTRAL-NERVOUS-SYSTEM; PRIMITIVE NEUROECTODERMAL TUMORS; TERATOID RHABDOID TUMORS; LOW-GRADE GLIOMAS; CRANIOSPINAL RADIATION-THERAPY; INTRINSIC PONTINE GLIOMA; HIGH-DOSE CHEMOTHERAPY; EMBRYONAL TUMOR; CHILDHOOD MEDULLOBLASTOMA; PILOCYTIC ASTROCYTOMAS;

D O I：

10.1200/JCO.2014.59.9217

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the past 5 years. This article summarizes data from collaborative group and institutional trials that have advanced the science of pediatric brain tumors and survival of patients with these tumors. Advanced genomic analysis of the entire spectrum of pediatric brain tumors has heralded an era in which stakeholders in the pediatric neuro-oncology community are being challenged to reconsider their current research and diagnostic and treatment strategies. The incorporation of this new information into the next-generation treatment protocols will unleash new challenges. This review succinctly summarizes the key advances in our understanding of the common pediatric brain tumors (ie, medulloblastoma, low- and high-grade gliomas, diffuse intrinsic pontine glioma, and ependymoma) and some selected rare tumors (ie, atypical teratoid/rhabdoid tumor and CNS primitive neuroectodermal tumor). The potential impact of this new information on future clinical protocols also is discussed. Cutting-edge genomics technologies and the information gained from such studies are facilitating the identification of molecularly defined subgroups within patients with particular pediatric brain tumors. The number of evaluable patients in each subgroup is small, particularly in the subgroups of rare diseases. Therefore, international collaboration will be crucial to draw meaningful conclusions about novel approaches to treating pediatric brain tumors. (C) 2015 by American Society of Clinical Oncology

引用

页码：2986 / U83

页数：15

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