Straightforward Access to Water-Soluble Unsymmetrical Sulfoxanthene Dyes: Application to the Preparation of Far-Red Fluorescent Dyes with Large Stokes' Shifts

被引：38

作者：

Chevalier, Arnaud ^{[1
,2
,3
,4
]}

Renard, Pierre-Yves ^{[1
,2
,3
,4
]}

Romieu, Anthony ^{[5
]}

机构：

[1] Normandie Univ, COBRA UMR 6014, F-76821 Mont St Aignan, France

[2] Univ Rouen, FR 3038, F-76821 Mont St Aignan, France

[3] INSA Rouen, F-76821 Mont St Aignan, France

[4] CNRS, IRCOF, F-76821 Mont St Aignan, France

[5] Univ Bourgogne, ICMUB, CNRS, UMR 6302, F-21078 Dijon, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 27期

关键词：

far-red dyes; fluorescent probes; rhodamines; rhodols; Stokes' shift; NEAR-INFRARED DYES; EMITTING RHODAMINE DYES; IN-VIVO; RATIONAL DESIGN; LONG-WAVELENGTH; XANTHENE DYES; SI-RHODAMINE; SPECTROSCOPIC PROPERTIES; PHOTOPHYSICAL PROPERTIES; FLUOROGENIC PROBES;

D O I：

10.1002/chem.201402306

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of water-soluble unsymmetrical sulforhodamine/sulforhodol fluorophores containing a single julolidine fragment is presented. Owing to their valuable spectral properties in aqueous buffers, these dyes, especially those bearing a free aniline or phenol moiety, are valuable components of fluorogenic probes for a variety of biosensing applications. A further extension of this synthetic methodology to unusual phenols, namely 7-N,N-dialkylamino-4-hydroxy coumarins has enabled us to provide a new family water-soluble dyes of large Stokes' shift with far-red spectral features.

引用

页码：8330 / 8337

页数：8

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