Pathophysiology of Cisplatin-Induced Acute Kidney Injury

被引:513
作者
Ozkok, Abdullah [1 ]
Edelstein, Charles L. [1 ]
机构
[1] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO 80262 USA
关键词
ACUTE-RENAL-FAILURE; MESENCHYMAL STEM-CELLS; OXYGENASE-1 GENE ABLATION; COPPER TRANSPORTER CTR1; INDUCED NEPHROTOXICITY; DENDRITIC CELLS; IN-VITRO; INDUCED APOPTOSIS; HEME OXYGENASE-1; MITOCHONDRIAL DYSFUNCTION;
D O I
10.1155/2014/967826
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. There is predominantly acute tubular necrosis and also apoptosis in the proximal tubules. There is activation of multiple proinflammatory cytokines and infiltration of inflammatory cells in the kidney. Inhibition of the proinflammatory cytokines TNF-alpha or IL-33 or depletion of CD4+ T cells or mast cells protects against cisplatin-induced AKI. Cisplatin also causes endothelial cell injury. An understanding of the pathogenesis of cisplatin-induced AKI is important for the development of adjunctive therapies to prevent AKI, to lessen the need for dose decrease or drug withdrawal, and to lessen patient morbidity and mortality.
引用
收藏
页数:17
相关论文
共 172 条
  • [1] Agarwal A, 2000, J AM SOC NEPHROL, V11, P965, DOI 10.1681/ASN.V115965
  • [2] INDUCTION OF HEME OXYGENASE IN TOXIC RENAL INJURY - A PROTECTIVE ROLE IN CISPLATIN NEPHROTOXICITY IN THE RAT
    AGARWAL, A
    BALLA, J
    ALAM, J
    CROATT, AJ
    NATH, KA
    [J]. KIDNEY INTERNATIONAL, 1995, 48 (04) : 1298 - 1307
  • [3] Co-supplementation of single and multi doses of vitamins C and E ameliorates cisplatin-induced acute renal failure in mice
    Ajith, T. A.
    Abhishek, G.
    Roshny, D.
    Sudheesh, N. P.
    [J]. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2009, 61 (06) : 565 - 571
  • [4] IL-33 Exacerbates Acute Kidney Injury
    Akcay, Ali
    Quocan Nguyen
    He, Zhibin
    Turkmen, Kultigin
    Lee, Dong Won
    Hernando, Ana Andres
    Altmann, Christopher
    Toker, Aysun
    Pacic, Arijana
    Ljubanovic, Danica Galesic
    Jani, Alkesh
    Faubel, Sarah
    Edelstein, Charles L.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (11): : 2057 - 2067
  • [5] Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells
    Arany, I
    Megyesi, JK
    Kaneto, H
    Price, PM
    Safirstein, RL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (03) : F543 - F549
  • [6] Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells
    Arany, Istvan
    Herbert, Johann
    Herbert, Zsolt
    Safirstein, Robert L.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 294 (03) : F577 - F581
  • [7] Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity
    Aydinoz, Seed
    Uzun, Gunalp
    Cermik, Hakan
    Atasoyu, Enes Murat
    Yidiz, Senol
    Karagoz, Bulent
    Evrenkaya, Rifki
    [J]. RENAL FAILURE, 2007, 29 (03) : 257 - 263
  • [8] Role of cytochrome P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicity
    Baliga, R
    Zhang, ZW
    Baliga, M
    Ueda, N
    Shah, SV
    [J]. KIDNEY INTERNATIONAL, 1998, 54 (05) : 1562 - 1569
  • [9] In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity
    Baliga, R
    Zhang, ZW
    Baliga, M
    Ueda, N
    Shah, SV
    [J]. KIDNEY INTERNATIONAL, 1998, 53 (02) : 394 - 401
  • [10] Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
    Bamboat, Zubin M.
    Ocuin, Lee M.
    Balachandran, Vinod P.
    Obaid, Hebroon
    Plitas, George
    DeMatteo, Ronald P.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) : 559 - 569