Histone-inspired biomimetic polymeric gene vehicles with excellent biocompatibility and enhanced transfection efficacy

被引：15
作者：
Cui, Peng-Fei [1 ]
Zhuang, Wan-Ru [1 ]
Qiao, Jian-Bin [1 ]
Zhang, Jia-Liang [1 ]
He, Yu-Jing [1 ]
Luo, Cheng-Qiong [1 ]
Jin, Qing-Ri [4 ]
Xing, Lei [1 ]
Jiang, Hu-Lin [1 ,2 ,3 ]
机构：
[1] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China
[4] Zhejiang A&F Univ, Coll Anim Sci & Technol, Linan 311300, Zhejiang, Peoples R China
来源：
POLYMER CHEMISTRY | 2016年 / 7卷 / 48期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
PROTON SPONGE HYPOTHESIS; SIRNA DELIVERY; THERMOPHILIC HISTONE; POLY(AMIDO AMINE)S; HIGHLY EFFICIENT; IN-VITRO; DNA; CARRIERS; POLYETHYLENIMINE; NANOPARTICLES;
D O I：
10.1039/c6py01703g
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Limited delivery options have hindered the development of nucleic acid drugs in clinical practice. Inspired by the natural DNA compressing ability of histones, herein we have synthesized novel polymeric carriers called PCA(m)H(n) designed to mimic the histone mechanism for gene delivery. These smart polymers, composed of cell penetrating guanidine groups and pH sensitive imidazole groups, exhibited superior transfection efficiency. Simultaneously, GSH-responsive degradation endowed PCA(m)H(n) with capabilities of real-time DNA release as well as timely biodegradation. In summary, these histone-inspired PCA(m)H(n) have shown a great potential in gene therapy.
引用
收藏
页码：7416 / 7426
页数：11
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