Haemophilus influenzae type b reemergence after combination immunization

被引：41
作者：
Johnson, Nik G.
Ruggeberg, Jens U.
Balfour, Gail F.
Lee, Y. Chen
Liddy, Helen
Irving, Diane
Sheldon, Joanna
Slack, Mary P. E.
Pollard, Andrew J.
Heath, Paul I. [1 ]
机构：
[1] St Georges Univ London, London, England
[2] Univ Oxford, Oxford OX1 2JD, England
[3] St George Hosp, London, England
[4] Hlth Protect Agcy Ctr Infect, London, England
来源：
EMERGING INFECTIOUS DISEASES | 2006年 / 12卷 / 06期
关键词：
D O I：
10.3201/eid1206.051451
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 mu g/mL, 95% confidence interval [CI] 0.36-0.58; geometric mean avidity index 0.16, 95% Cl 0.14-0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p < 0.001, respectively). Hib was found in 2.1% (95% Cl 0.7%-6.0%) of study participants. Our data support an association between DTaP-Hib vaccine combinations and clinical Hib disease through an effect on antibody concentration and avidity.
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收藏
页码：937 / 941
页数：5
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