Impaired peripheral glucose homeostasis and Alzheimer's disease

被引：65
作者：
Wijesekara, Nadeeja [1 ]
Goncalves, Rafaella Araujo [1 ,2 ]
De Felice, Fernanda G. [2 ,3 ]
Fraser, Paul E. [1 ,4 ]
机构：
[1] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Krembil Discovery Tower,60 Leonard Ave, Toronto, ON MST 2S8, Canada
[2] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil
[3] Queens Univ, Ctr Neurosci Studies, Dept Biomed & Mol Sci, Kingston, ON K7L 3N6, Canada
[4] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
来源：
NEUROPHARMACOLOGY | 2018年 / 136卷
基金：
加拿大健康研究院;
关键词：
Type; 2; diabetes; Alzheimer's disease; Amyloid-beta (A beta); Islet amyloid polypeptide (IAPP); Insulin resistance; AMYLOID-BETA-PROTEIN; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; HEPATIC INSULIN-RESISTANCE; BRAIN INSULIN; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; DIABETES-MELLITUS; BODY-WEIGHT;
D O I：
10.1016/j.neuropharm.2017.11.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is the most common type of dementia. Recent studies suggest that metabolic disturbances, particularly type 2 diabetes (T2D) increase the risk of cognitive decline and AD. AD is also a risk factor for T2D, and a growing body of evidence indicates that these diseases are connected both at clinical and molecular levels. In T2D, peripheral insulin resistance, hyperglycemia and eventually insulin deficiency develops, leading to an overall decline in tissue health. More recently, brain insulin resistance has been shown to be a key feature of AD that is linked to neuronal dysfunction and cognitive impairment. Furthermore, both AD and T2D are amyloidogenic diseases, with abnormal aggregation of amyloid-beta peptide (A beta) and islet amyloid polypeptide (IAPP) respectively contributing to cellular death and disease pathogenesis. Emerging data suggests that A beta may have peripheral effects including its co-deposition in the pancreas. In this review, we discuss how peripheral effects of A beta and metabolic disturbances may impact AD pathogenesis. This article is part of the Special Issue entitled 'Metabolic Impairment as Risk Factors for Neurodegenerative Disorders.' (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：172 / 181
页数：10
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