Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5

被引：10

作者：

Hussey, DJ

Parker, NJ

Hussey, ND

Little, PFR

Dobrovic, A

机构：

[1] QUEEN ELIZABETH HOSP,DEPT HAEMATOL ONCOL,WOODVILLE,SA 5011,AUSTRALIA

[2] UNIV ADELAIDE,QUEEN ELIZABETH HOSP,DEPT MED,WOODVILLE,SA 5011,AUSTRALIA

[3] ROYAL CHILDRENS HOSP,DEPT HAEMATOL ONCOL,PARKVILLE,VIC 3052,AUSTRALIA

[4] UNIV ADELAIDE,QUEEN ELIZABETH HOSP,DEPT OBSTET & GYNAECOL,WOODVILLE,SA 5011,AUSTRALIA

[5] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM,LONDON,ENGLAND

来源：

GENOMICS | 1997年 / 45卷 / 02期

关键词：

D O I：

10.1006/geno.1997.4958

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the cDNA sequence of the zinc finger gene, ZNF195, which maps to chromosome 11p15.5. ZNF195 contains an N-terminal KRAB domain and 14 tandemly repeated Kruppel type zinc finger motifs at its C-terminus. Northern analysis shows expression of ZNF195 in adult heart, brain, placenta, skeletal muscle, and pancreas with a predominant transcript size of 4.3 kb. There is little expression in adult lung, liver, and kidney. In fetal lung, liver, kidney, and brain, the predominant transcript is 3.5 kb. Fetal brain also expresses a 4.3-kb transcript. RT-PCR analysis shows that two exons, 4a, which contains an inverted Alu sequence, and 4b, are differentially spliced and absent from the major transcript. (C) 1997 Academic Press.

引用

页码：451 / 455

页数：5

共 18 条

[1] THE EVOLUTIONARILY CONSERVED KRUPPEL-ASSOCIATED BOX DOMAIN DEFINES A SUBFAMILY OF EUKARYOTIC MULTIFINGERED PROTEINS [J].