Peroxisome proliferator-activated receptor α/γ dual Agonists for the treatment of type 2 diabetes

被引：130
作者：
Henke, BR [1 ]
机构：
[1] GlaxoSmithKline, Metab & Viral Dis Drug Discovery Res, Res Triangle Pk, NC 27709 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 17期
关键词：
D O I：
10.1021/jm030631e
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：4118 / 4127
页数：10
相关论文
共 63 条
[1]   Amphipathic 3-phenyl-7-propylbenziscoxazoles;: human PPaR γ, δ and α agonists [J].
Adams, AD ;
Yuen, W ;
Hu, Z ;
Santini, C ;
Jones, AB ;
MacNaul, KL ;
Berger, JP ;
Doebber, TW ;
Moller, DE .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (05) :931-935
[2]   Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity -: Studies with congenic mouse lines [J].
Akiyama, TE ;
Nicol, CJ ;
Fievet, C ;
Staels, B ;
Ward, JM ;
Auwerx, J ;
Lee, SST ;
Gonzalez, FJ ;
Peters, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :39088-39093
[3]   Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) [J].
Aoyama, T ;
Peters, JM ;
Iritani, N ;
Nakajima, T ;
Furihata, K ;
Hashimoto, T ;
Gonzalez, FJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5678-5684
[4]   Insulin resistance in type 2 diabetes: role of fatty acids [J].
Arner, P .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2002, 18 :S5-S9
[5]   PPARγ, the ultimate thrifty gene [J].
Auwerx, J .
DIABETOLOGIA, 1999, 42 (09) :1033-1049
[6]   Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis [J].
Barbier, O ;
Torra, IP ;
Duguay, Y ;
Blanquart, C ;
Fruchart, JC ;
Glineur, C ;
Staels, B .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (05) :717-726
[7]  
Bocher V, 2002, ANN NY ACAD SCI, V967, P7
[8]   Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction [J].
Boden, G ;
Shulman, GI .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 :14-23
[9]  
Boden G., 2001, Curr.Opin.Endocrinol.Diabetes, V8, P235
[10]   Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl)ethoxy]phenoxy}propionic acids:: A new class of dual PPARα/γ agonists [J].
Brooks, DA ;
Etgen, GJ ;
Rito, CJ ;
Shuker, AJ ;
Dominianni, SJ ;
Warshawsky, AM ;
Ardecky, R ;
Paterniti, JR ;
Tyhonas, J ;
Karanewsky, DS ;
Kauffman, RF ;
Broderick, CL ;
Oldham, BA ;
Montrose-Rafizadeh, C ;
Winneroski, LL ;
Faul, MM ;
McCarthy, JR .
JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (13) :2061-2064
1234567