LncRNA MIAT facilitates osteosarcoma progression by regulating mir-128-3p/VEGFC axis

被引：31
作者：
Zhang, Chunyan [1 ]
Xie, Linsen [1 ]
Liang, Huiling [2 ]
Cui, Yuanbo [3 ,4 ]
机构：
[1] Zhengzhou Univ, Dept Clin Lab, Zhengzhou Cent Hosp, Zhengzhou, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Oncol, Zhengzhou, Henan, Peoples R China
[3] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China
[4] Zhengzhou Univ, Zhengzhou Cent Hosp, Translat Med Ctr, Zhengzhou 450007, Henan, Peoples R China
来源：
IUBMB LIFE | 2019年 / 71卷 / 07期
关键词：
LncRNA; MIAT; miR-128-3p; VEGFC; osteosarcoma; NONCODING RNA MIAT; CANCER PROGRESSION; PROLIFERATION; METASTASIS; EXPRESSION; GENE;
D O I：
10.1002/iub.2001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aberrant expression of long non-coding RNAs (lncRNAs) has been involved in the progression of many human tumors including osteosarcoma (OS). However, the biological function and the underlying mechanism of the lncRNA myocardial infarction-associated transcript (MIAT) in OS remain unclear. In the present study, we found that lncRNA MIAT was significantly up-regulated in both OS tissues and cell lines, and high expression of MIAT was positively associated with tumor size and lymph node metastasis of OS patients. In addition, knockdown of MIAT inhibited proliferation, migration, invasion and promoted apoptosis of OS cells in vitro. Moreover, the expression of MIAT was negatively associated with miR-128-3p but positively correlated with vascular endothelial growth factor C (VEGFC) in OS. Further mechanistic study revealed that lncRNA MIAT promoted OS progression by up-regulating VEGFC via sponging miR-128-3p in vitro. Taken together, our results suggest that MIAT/miR-128-3p/VEGFC axis contributes to OS progression and may be used as a novel therapeutic target for OS. (c) 2019 IUBMB Life, 9999(9999):1-9, 2019
引用
收藏
页码：845 / 853
页数：9
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