Copper-catalyzed direct C-H fluoroalkenylation of heteroarenes

被引：17
作者：
Rousee, Kevin
Schneider, Cedric
Bouillon, Jean-Philippe
Levacher, Vincent
Hoarau, Christophe [1 ]
Couve-Bonnaire, Samuel
Pannecoucke, Xavier
机构：
[1] Normandie Univ, COBRA, UMR 6014, F-76821 Mont St Aignan, France
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 01期
关键词：
MEDIATED DIRECT ARYLATION; CARBON-CARBON BONDS; DIRECT ALKYNYLATION; PALLADIUM; FLUORINE; 1,1-DIBROMO-1-ALKENES; FUNCTIONALIZATION; HYDROGEN; 1,3,4-OXADIAZOLES; PHARMACEUTICALS;
D O I：
10.1039/c5ob02213d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed direct C-H fluoroalkenylation of heterocycles using various gem-bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of biomolecules and therapeutic agents for the treatment of Duchenne muscular dystrophy as application is reported.
引用
收藏
页码：353 / 357
页数：5
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