Synthesis and biological evaluation of a series of 1,4-disubstituted 1,2,3-triazole derivatives as possible antimicrobial agents

被引：39

作者：

Jadhav, Rahul P. ^{[1
]}

Raundal, Hemant N. ^{[1
]}

Patil, Amar A. ^{[1
]}

Bobade, Vivek D. ^{[1
]}

机构：

[1] HPT Arts & RYK Sci Coll, Dept Chem, Nasik 422005, Maharashtra, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2017年 / 21卷 / 02期

关键词：

1,3,4-Oxadiazole; Piperazine; Antibacterial activity; Antifungal activity; 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES; INHIBITORS; BEARING; HYBRIDS; DESIGN;

D O I：

10.1016/j.jscs.2015.03.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three series of novel compounds derived from 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid bearing piperazine carboxamides, (5-(substituted phenyl)-1,3,4-oxadiazol-2-yl) and (5-(alkylthio)-1,3,4-oxadiazol-2-yl) substitutions at the 4-position were synthesized. Synthesized compounds were characterized by H-1 NMR, C-13 NMR and mass spectral analysis and evaluated for their antimicrobial activities. Interestingly, most of the compounds exhibit moderate to good activities against tested Gram-positive, Gram-negative bacterial strains as well as fungal strains. (C) 2015 The Authors. Production and hosting by Elsevier B. V. on behalf of King Saud University. This is an open access article under theCCBY-NC-ND license.

引用

页码：152 / 159

页数：8

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