Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines

被引：2

作者：

Ananthan, S ^{[1
]}

Saini, SK

Khare, R

Clayton, SD

Dersch, CM

Rothman, RB

机构：

[1] So Res Inst, Organ Chem Dept, Birmingham, AL 35255 USA

[2] NIDA, IRP, Clin Psychopharmacol Sect, Baltimore, MD 21224 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(02)00348-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an attempt to identify novel ligands for the dopamine transporter, a series of 4-substituted-2-phenylquinazolines were synthesized and evaluated. Among the compounds studied, 4-[(diphenylmethyl)amino]-2-phenylquinazoline (4g) was identified as a novel partial inhibitor of [I-125]RTI-55 binding to the dopamine transporter and a partial inhibitor of [H-3]dopamine uptake. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2225 / 2228

页数：4

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