Polyethylenimine In Medicinal Chemistry

被引：96

作者：

Vicennati, Paola ^{[1
]}

Giuliano, Antonella ^{[1
]}

Ortaggi, Giancarlo ^{[1
]}

Masotti, Andrea ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2008年 / 15卷 / 27期

关键词：

Polyethylenimine; polymer; DNA; transfection; gene therapy; drug delivery; medicinal chemistry; biomedical applications;

D O I：

10.2174/092986708786242778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.

引用

页码：2826 / 2839

页数：14

共 61 条

[1] Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis [J].

Akinc, A ;

Thomas, M ;

Klibanov, AM ;

Langer, R .

JOURNAL OF GENE MEDICINE, 2005, 7 (05) :657-663

[2] POLYETHYLENEIMINE IN IMMOBILIZATION OF BIOCATALYSTS [J].

BAHULEKAR, R ;

AYYANGAR, NR ;

PONRATHNAM, S .

ENZYME AND MICROBIAL TECHNOLOGY, 1991, 13 (11) :858-868

[3] Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans [J].

Beyth, N ;

Yudovin-Farber, I ;

Bahir, R ;

Domb, AJ ;

Weissa, E .

BIOMATERIALS, 2006, 27 (21) :3995-4002

[4] In vitro and in vivo evaluation of pectin beads for the colon delivery of β-lactamases [J].

Bourgeois, S ;

Laham, A ;

Besnard, M ;

Andremont, A ;

Fattal, E .

JOURNAL OF DRUG TARGETING, 2005, 13 (05) :277-284

[5]

BOURGEOIS S, 2003, PCTFR0302474

[6] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[7]

*CHEM SAF INF INT, 2008, 121205 CHEM SAF INF

[8] Novel anticoagulant polyethylenimine: Inhibition of thrombin-catalyzed fibrin formation [J].

Chu, AJ ;

Beydoun, S ;

Mathews, ST ;

Hoang, J .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2003, 415 (01) :101-108

[9] A MODEL STUDY ON EUDRAGIT AND POLYETHYLENEIMINE AS SOLUBLE CARRIERS OF ALPHA-AMYLASE FOR REPEATED HYDROLYSIS OF STARCH [J].

CONG, L ;

KAUL, R ;

DISSING, U ;

MATTIASSON, B .

JOURNAL OF BIOTECHNOLOGY, 1995, 42 (01) :75-84

[10] PRECIPITATION OF NUCLEIC-ACIDS WITH POLY(ETHYLENEIMINE) [J].

CORDES, RM ;

SIMS, WB ;

GLATZ, CE .

BIOTECHNOLOGY PROGRESS, 1990, 6 (04) :283-285

← 1 2 3 4 5 6 7 →