Biomaterials for tissue engineering applications

被引：114

作者：

Keane, Timothy J. ^{[1
,2
]}

Badylak, Stephen F. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA

[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15219 USA

[3] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15219 USA

来源：

SEMINARS IN PEDIATRIC SURGERY | 2014年 / 23卷 / 03期

关键词：

Tissue engineering; Biomaterials; Bioactive molecules; EXTRACELLULAR-MATRIX SCAFFOLD; MUSCLE-CELL-ADHESION; GROWTH-FACTOR; REGENERATIVE MEDICINE; OSTEOGENIC DIFFERENTIATION; FLUOROGENIC SUBSTRATE; BIOLOGIC SCAFFOLDS; STEM-CELLS; IN-VIVO; HYDROGELS;

D O I：

10.1053/j.sempedsurg.2014.06.010

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

With advancements in biological and engineering sciences, the definition of an ideal biomaterial has evolved over the past 50 years from a substance that is inert to one that has select bioinductive properties and integrates well with adjacent host tissue. Biomaterials are a fundamental component of tissue engineering, which aims to replace diseased, damaged, or missing tissue with reconstructed functional tissue. Most biomaterials are less than satisfactory for pediatric patients because the scaffold must adapt to the growth and development of the surrounding tissues and organs over time. The pediatric community, therefore, provides a distinct challenge for the tissue engineering community. (C) 2014 Published by Elsevier Inc.

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页码：112 / 118

页数：7

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