Dengue vaccine development by the year 2020: challenges and prospects

被引：64

作者：

Wilder-Smith, Annelies ^{[1
,2
]}

机构：

[1] London Sch Hyg & Trop Med, London, England

[2] Heidelberg Univ, Heidelberg Inst Global Hlth, Heidelberg, Germany

来源：

CURRENT OPINION IN VIROLOGY | 2020年 / 43卷

关键词：

HEALTHY-CHILDREN; GEOSENTINEL SURVEILLANCE; SEROSTATUS; RESPONSES; TRAVELERS; EFFICACY; ILLNESS; SAFETY;

D O I：

10.1016/j.coviro.2020.09.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The first licensed dengue vaccine led to considerable controversy, and to date, no dengue vaccine is in widespread use. All three leading dengue vaccine candidates are live attenuated vaccines, with the main difference between them being the type of backbone and the extent of chimerization. While CYD-TDV (the first licensed dengue vaccine) does not include non-structural proteins of dengue, TAK-003 contains the dengue virus serotype 2 backbone, and the Butantan/Merck vaccine contains three full-genomes of the four dengue virus serotypes. While dengue-primed individuals can already benefit from vaccination against all four serotypes with the first licensed dengue vaccine CYD-TDV, the need for dengue-naive population has not yet been met. To improve tetravalent protection, sequential vaccination should be considered in addition to a heterologous prime-boost approach.

引用

页码：71 / 78

页数：8

共 79 条

[1] Primary and Secondary Dengue Virus Infections Elicit Similar Memory B-Cell Responses, but Breadth to Other Serotypes and Cross-Reactivity to Zika Virus Is Higher in Secondary Dengue [J].

Andrade, Paulina ;

Narvekar, Parnal ;

Montoya, Magelda ;

Michlmayr, Daniela ;

Balmaseda, Angel ;

Coloma, Josefina ;

Harris, Eva .

JOURNAL OF INFECTIOUS DISEASES, 2020, 222 (04) :590-600

[2] Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika [J].

Andrade, Paulina ;

Gimblet-Ochieng, Ciara ;

Modirian, Faraz ;

Collins, Matthew ;

Cardenas, Maritza ;

Katzelnick, Leah C. ;

Montoya, Magelda ;

Michlmayr, Daniela ;

Kuan, Guillermina ;

Balmaseda, Angel ;

Coloma, Josefina ;

de Silva, Aravinda M. ;

Harris, Eva .

NATURE COMMUNICATIONS, 2019, 10 (1)

[3] Illness among US resident student travellers after return to the USA: a GeoSentinel analysis, 2007-17 [J].

Angelo, Kristina M. ;

Haulman, N. Jean ;

Terry, Anne C. ;

Leung, Daniel T. ;

Chen, Lin H. ;

Barnett, Elizabeth D. ;

Hagmann, Stefan H. F. ;

Hynes, Noreen A. ;

Connor, Bradley A. ;

Anderson, Susan ;

McCarthy, Anne ;

Shaw, Marc ;

Van Genderen, Perry J. J. ;

Hamer, Davidson H. .

JOURNAL OF TRAVEL MEDICINE, 2018, 25

[4] What proportion of international travellers acquire a travel-related illness? A review of the literature [J].

Angelo, Kristina M. ;

Kozarsky, Phyllis E. ;

Ryan, Edward T. ;

Chen, Lin H. ;

Sotir, Mark J. .

JOURNAL OF TRAVEL MEDICINE, 2017, 24 (05)

[5] Human CD4+ T Cell Responses to an Attenuated Tetravalent Dengue Vaccine Parallel Those Induced by Natural Infection in Magnitude, HLA Restriction, and Antigen Specificity [J].

Angelo, Michael A. ;

Grifoni, Alba ;

O'Rourke, Patrick H. ;

Sidney, John ;

Paul, Sinu ;

Peters, Bjoern ;

de Silva, Aruna D. ;

Phillips, Elizabeth ;

Mallal, Simon ;

Diehl, Sean A. ;

Kirkpatrick, Beth D. ;

Whitehead, Stephen S. ;

Durbin, Anna P. ;

Sette, Alessandro ;

Weiskopf, Daniela .

JOURNAL OF VIROLOGY, 2017, 91 (05)

[6] Timing of administration of dengue vaccine in travellers with a recent confirmed dengue infection [J].

Batchelor, Trish .

JOURNAL OF TRAVEL MEDICINE, 2018, 25

[7] Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination [J].

Beatty, P. Robert ;

Puerta-Guardo, Henry ;

Killingbeck, Sarah S. ;

Glasner, Dustin R. ;

Hopkins, Kaycie ;

Harris, Eva .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (304)

[8] Efficacy of a tetravalent dengue vaccine in healthy children aged 4-16 years: a randomised, placebo-controlled, phase 3 trial [J].

Biswal, Shibadas ;

Borja-Tabora, Charissa ;

Martinez Vargas, Luis ;

Velasquez, Hector ;

Theresa Alera, Maria ;

Sierra, Victor ;

Johana Rodriguez-Arenales, Edith ;

Yu, Delia ;

Wickramasinghe, Pujitha ;

Moreira, Edson Duarte, Jr. ;

Fernando, Asvini D. ;

Gunasekera, Dulanie ;

Kosalaraksa, Pope ;

Espinoza, Felix ;

Lopez-Medina, Eduardo ;

Bravo, Lulu ;

Tuboi, Suely ;

Hutagalung, Yanee ;

Garbes, Pedro ;

Escudero, Ian ;

Rauscher, Martina ;

Bizjajeva, Svetlana ;

LeFevre, Inge ;

Borkowski, Astrid ;

Saez-Llorens, Xavier ;

Wallace, Derek .

LANCET, 2020, 395 (10234) :1423-1433

[9] Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents [J].

Biswal, Shibadas ;

Reynales, Humberto ;

Saez-Llorens, Xavier ;

Lopez, Pio ;

Borja-Tabora, Charissa ;

Kosalaraksa, Pope ;

Sirivichayakul, Chukiat ;

Watanaveeradej, Veerachai ;

Rivera, Luis ;

Espinoza, Felix ;

Fernando, LakKumar ;

Dietze, Reynaldo ;

Luz, Kleber ;

da Cunha, Rivaldo Venancio ;

Jimeno, Jose ;

Lopez-Medina, Eduardo ;

Borkowski, Astrid ;

Brose, Manja ;

Rauscher, Martina ;

LeFevre, Inge ;

Bizjajeva, Svetlana ;

Bravo, Lulu ;

Wallace, Derek .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (21) :2009-2019

[10] Evaluation of rapid diagnostic tests and conventional enzyme-linked immunosorbent assays to determine prior dengue infection [J].

Bonaparte, Matthew ;

Zheng, Lingyi ;

Garg, Sanjay ;

Guy, Bruno ;

Lustig, Yaniv ;

Schwartz, Eli ;

DiazGranados, Carlos A. ;

Savarino, Stephen ;

Ataman-Onal, Yasemin .

JOURNAL OF TRAVEL MEDICINE, 2019, 26 (08)

← 1 2 3 4 5 6 7 8 →