MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

被引：165
|
作者：
Houzet, Laurent [1 ]
Yeung, Man Lung [1 ]
de Lame, Valery [2 ]
Desai, Dhara [2 ]
Smith, Stephen M. [2 ]
Jeang, Kuan-Teh [1 ]
机构：
[1] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA
[2] St Michaels Hosp, Dept Infect Dis, Newark, NJ 07102 USA
来源：
RETROVIROLOGY | 2008年 / 5卷 / 1期
关键词：
D O I：
10.1186/1742-4690-5-118
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
MicroRNAs ( miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.
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页数：9
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