MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals

被引：165

作者：

Houzet, Laurent ^{[1
]}

Yeung, Man Lung ^{[1
]}

de Lame, Valery ^{[2
]}

Desai, Dhara ^{[2
]}

Smith, Stephen M. ^{[2
]}

Jeang, Kuan-Teh ^{[1
]}

机构：

[1] NIAID, Mol Virol Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[2] St Michaels Hosp, Dept Infect Dis, Newark, NJ 07102 USA

来源：

RETROVIROLOGY | 2008年 / 5卷 / 1期

关键词：

D O I：

10.1186/1742-4690-5-118

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MicroRNAs ( miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.

引用

页数：9