CellFinder: a cell data repository

被引：18

作者：

Stachelscheid, Harald ^{[1
]}

Seltmann, Stefanie ^{[1
]}

Lekschas, Fritz ^{[1
]}

Fontaine, Jean-Fred ^{[2
]}

Mah, Nancy ^{[2
]}

Neves, Mariana ^{[3
]}

Andrade-Navarro, Miguel A. ^{[2
]}

Leser, Ulf ^{[3
]}

Kurtz, Andreas ^{[1
,4
,5
]}

机构：

[1] Charite, Berlin Brandenburg Ctr Regenerat Med, D-13353 Berlin, Germany

[2] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[3] Humboldt Univ, Inst Comp Sci, D-10099 Berlin, Germany

[4] Seoul Natl Univ, Coll Vet Med, Seoul 151742, South Korea

[5] Seoul Natl Univ, Res Inst Vet Sci, Seoul 151742, South Korea

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

关键词：

GENE-EXPRESSION; ONTOLOGY; TOOL; MICROARRAY; EVOLUTION; RESOURCE; MODEL;

D O I：

10.1093/nar/gkt1264

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CellFinder (http://www.cellfinder.org) is a comprehensive one-stop resource for molecular data characterizing mammalian cells in different tissues and in different development stages. It is built from carefully selected data sets stemming from other curated databases and the biomedical literature. To date, CellFinder describes 3394 cell types and 50 951 cell lines. The database currently contains 3055 microscopic and anatomical images, 205 whole-genome expression profiles of 194 cell/tissue types from RNA-seq and microarrays and 553 905 protein expressions for 535 cells/tissues. Text mining of a corpus of >2000 publications followed by manual curation confirmed expression information on similar to 900 proteins and genes. CellFinder's data model is capable to seamlessly represent entities from single cells to the organ level, to incorporate mappings between homologous entities in different species and to describe processes of cell development and differentiation. Its ontological backbone currently consists of 204 741 ontology terms incorporated from 10 different ontologies unified under the novel CELDA ontology. CellFinder's web portal allows searching, browsing and comparing the stored data, interactive construction of developmental trees and navigating the partonomic hierarchy of cells and tissues through a unique body browser designed for life scientists and clinicians.

引用

页码：D950 / D958

页数：9

共 49 条

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