Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

被引：50

作者：

Xie, Hong-Yan ^{[1
,2
,3
,4
]}

Shao, Zhi-Min ^{[1
,2
,3
,4
,5
,6
]}

Li, Da-Qiang ^{[1
,2
,3
,4
,5
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Inst Canc, Shanghai 200032, Peoples R China

[4] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[5] Fudan Univ, Shanghai Med Coll, Key Lab Breast Canc Shanghai, Shanghai 200032, Peoples R China

[6] Fudan Univ, Shanghai Med Coll, Dept Breast Surg, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CANCER | 2017年 / 36卷

基金：

中国国家自然科学基金;

关键词：

Breast cancer; Invasion and metastasis; Tumor microenvironment; TO-MESENCHYMAL TRANSITION; NF-KAPPA-B; CHEMOKINE RECEPTORS; BONE METASTASIS; LUNG METASTASIS; STEM-CELLS; INFLAMMATORY MONOCYTES; MOLECULAR-MECHANISMS; LYSYL OXIDASE; INVASION;

D O I：

10.1186/s40880-017-0202-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Distant metastasis to specific target organs is responsible for over 90% of breast cancer-related deaths, but the underlying molecular mechanism is unclear. Mounting evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ-specific metastasis of this lethal disease. Here, we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis; we also discuss potential therapeutic intervention strategies aimed at targeting components of the tumor microenvironment.

引用

页数：10

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