Paclitaxel chemotherapy for the treatment of gastric cancer

被引：114
作者：
Sakamoto, Junichi [1 ]
Matsui, Takanori [3 ]
Kodera, Yasuhiro [2 ]
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Young Leaders Program Med Adm, Showa Ku, Aichi 4668550, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Digest Surg, Nagoya, Aichi 4648601, Japan
[3] Aichi Hosp, Aichi Canc Ctr, Dept Surg, Okazaki, Aichi, Japan
来源：
GASTRIC CANCER | 2009年 / 12卷 / 02期
关键词：
Paclitaxel; Gastric cancer; Chemotherapy; PHASE-II TRIAL; CISPLATIN COMBINATION CHEMOTHERAPY; CONTINUOUS-INFUSION; 5-FLUOROURACIL; LOW-DOSE PACLITAXEL; BIWEEKLY PACLITAXEL; CLINICAL-TRIAL; ADJUVANT CHEMORADIATION; PATHOLOGICAL RESPONSE; CONCURRENT RADIATION; PLUS PACLITAXEL;
D O I：
10.1007/s10120-009-0505-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A comprehensive review of phase I and phase II clinical trials of paclitaxel and paclitaxel-containing chemotherapy regimens for advanced gastric cancer was performed. Response rates, median progression-free survivals, and median overall survivals were examined, together with the treatment regimens and the numbers of patients registered in each trial. Although paclitaxel monotherapy produced considerable improvement in tumor response and prognosis, combination doublet or triplet chemotherapy with fluoropyrimidines and/or platinum compounds showed better results than the paclitaxel monotherapy. With regard to the schedule of paclitaxel administration, weekly injection seemed to show less toxicity and better results than administration every 3 weeks. Adjuvant therapies, chemoradiation therapies, and paclitaxel treatment for gastric ascites were also investigated and are discussed.
引用
收藏
页码：69 / 78
页数：10
相关论文
共 87 条
[41]   Adjuvant chemoradiation using 5-fluorouracil/folinic acid/cisplatin with or without paclitaxel and radiation in patients with completely resected high-risk gastric cancer: two cooperative phase II studies of the AIO/ARO/ACO [J].
Kollmannsberger, C ;
Budach, W ;
Stahl, M ;
Schleucher, N ;
Hehr, T ;
Wilke, H ;
Schleicher, J ;
Vanhoefer, U ;
Jehle, EC ;
Oechsle, K ;
Trarbach, T ;
Boehlke, I ;
Kanz, L ;
Hartmann, JT ;
Bokemeyer, C .
ANNALS OF ONCOLOGY, 2005, 16 (08) :1326-1333
[42]   A phase II study of paclitaxel, weekly, 24-hour continuous infusion 5-fluorouracil, folinic acid and cisplatin in patients with advanced gastric cancer [J].
Kollmannsberger, C. ;
Quietzsch, D. ;
Haag, C. ;
Lingenfelsers, T. ;
Schroeder, M. ;
Hartmann, J. T. ;
Baronius, W. ;
Hempel, V. ;
Clemens, M. ;
Kanz, L. ;
Bokemeyer, C. .
BRITISH JOURNAL OF CANCER, 2000, 83 (04) :458-462
[43]   Phase I evaluation of continuous 5-fluorouracil infusion followed by weekly paclitaxel in patients with advanced or recurrent gastric cancer [J].
Kondo, K ;
Kobayashi, M ;
Kojima, H ;
Hirabayashi, N ;
Kataoka, M ;
Araki, K ;
Matsui, T ;
Takiyama, W ;
Miyashita, Y ;
Nakazato, H ;
Nakao, A ;
Sakamoto, J .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 35 (06) :332-337
[44]   Phase II trial of biweekly paclitaxel plus infusional 5-fluorouracil and leucovorin in patients with advanced or recurrent inoperable gastric cancer [J].
Lee, H. J. ;
Yun, H. J. ;
Kim, S. ;
Cho, D. Y. ;
Park, J. C. ;
Park, S. Y. ;
Bae, S. B. ;
Lee, K. T. ;
Cho, I. S. ;
Han, C. S. .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2009, 63 (03) :427-432
[45]   A multi-center phase II study of S-1 plus paclitaxel as first-line therapy for patients with advanced or recurrent unresectable gastric cancer [J].
Lee, Jae Jin ;
Kim, Si-Young ;
Chung, Hyun-Cheol ;
Lee, Kyung-Hee ;
Song, Hong-Suk ;
Kang, Won-Ki ;
Hong, Young-Seon ;
Choi, In-Sil ;
Lee, Young Yeul ;
Woo, In-Sook ;
Choi, Jin-Hyuk .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2009, 63 (06) :1083-1090
[46]   Phase II study of low-dose paclitaxel and cisplatin as a second-line therapy after 5-fluorouracil/platinum chemotherapy in gastric cancer [J].
Lee, Keun-Wook ;
Kim, Jee Hyun ;
Yun, Tak ;
Song, Eun Kee ;
Na, Im Il ;
Shin, Hytinchoon ;
Oh, So Yeon ;
Choi, In Sil ;
Oh, Do-Youn ;
Kim, Dong-Wan ;
Im, Seock-Ah ;
Kim, Tae-You ;
Lee, Jong Seok ;
Heo, Dae Seog ;
Bang, Yung-Jue ;
Kim, Noe Kyeong .
JOURNAL OF KOREAN MEDICAL SCIENCE, 2007, 22 :S115-S121
[47]   Phase II trial of low-dose paclitaxel and cisplatin in patients with advanced gastric cancer [J].
Lee, KW ;
Im, SA ;
Yun, T ;
Song, EK ;
Na, II ;
Shin, H ;
Choi, IS ;
Oh, DY ;
Kim, JH ;
Kim, DW ;
Kim, TY ;
Lee, JS ;
Heo, DS ;
Bang, YJ ;
Kim, NK .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2005, 35 (12) :720-726
[48]   Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. [J].
Macdonald, JS ;
Smalley, SR ;
Benedetti, J ;
Hundahl, SA ;
Estes, NC ;
Stemmermann, GN ;
Haller, DG ;
Ajani, JA ;
Gunderson, LL ;
Jessup, JM ;
Martenson, JA .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (10) :725-730
[49]   ANTIHISTAMINES IN THE TREATMENT OF TAXOL-INDUCED PAROXYSTIC PAIN SYNDROME [J].
MARTONI, A ;
ZAMAGNI, C ;
GHEKA, A ;
PANNUTI, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (08) :676-676
[50]   Phase I/II study of S-1 combined with paclitaxel in patients with unresectable and/or recurrent advanced gastric cancer [J].
Mochiki, E. ;
Ohno, T. ;
Kamiyama, Y. ;
Aihara, R. ;
Haga, N. ;
Ojima, H. ;
Nakamura, J. ;
Ohsawa, H. ;
Nakabayashi, T. ;
Takeuchi, K. ;
Asao, T. ;
Kuwano, H. .
BRITISH JOURNAL OF CANCER, 2006, 95 (12) :1642-1647
123456789