C-H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group

被引：19

作者：

Guo, Lingmei ^{[1
]}

Tang, Baolan ^{[1
]}

Nie, Ruifang ^{[1
]}

Liu, Yanzhao ^{[1
]}

Lv, Shan ^{[1
]}

Wang, Huijing ^{[2
]}

Guo, Li ^{[1
]}

Hai, Li ^{[1
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Dept Med Chem, 17,3th Sect,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

[2] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr, La Jolla, CA 92093 USA

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 71期

基金：

中国国家自然科学基金;

关键词：

C-8; POSITION; INDOLE ALKALOIDS; ACTIVATION; QUINOLINE; EFFICIENT; ANNULATION; ALKYNES; NITRONES; ACCESS; CYCLIZATION;

D O I：

10.1039/c9cc05719f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of transition-metal-catalyzed C-H activations of 2-phenylisatogens with alkynes and sulfonyl azides has been developed using N-oxide as the directing group. Ru(ii)-Catalyzed C-H alkenylation/cyclization and Ir(iii)-catalyzed direct C-H sulfamidation proceeded with good yields and excellent functional group tolerance. Importantly, these two transformations provided straightforward routes for the synthesis of indol-3-one derivatives and sulfamidated 2-phenylisatogens respectively, which might be of considerable bioactivities.

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收藏

页码：10623 / 10626

页数：4

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