Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

被引:14
作者
Chawla, Sharad [1 ]
Warren, Timothy A. [1 ,3 ,4 ]
Wockner, Leesa F. [3 ]
Lambie, Duncan L. J. [2 ,5 ]
Brown, Ian S. [6 ]
Martin, Thomas P. C. [1 ]
Khanna, Rajiv [3 ]
Leggatt, Graham R. [2 ]
Panizza, Benedict J. [1 ,4 ]
机构
[1] Princess Alexandra Hosp, Dept Otolaryngol Head & Neck Surg, 237 Ipswich Rd, Woolloongabba, Qld 4102, Australia
[2] Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia
[3] QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia
[4] Univ Queensland, Sch Med, Brisbane, Qld, Australia
[5] IQ Pathol, Brisbane, Qld, Australia
[6] Envoi Pathol, Brisbane, Qld, Australia
关键词
Perineural spread; Perineural tumour; microenvironment; Immunohistochemistry; Galectin-1; Lymphocytes; SQUAMOUS-CELL CARCINOMA; TUMOR-INFILTRATING LYMPHOCYTES; INCREASED EXPRESSION; COLORECTAL-CANCER; HISTOCOMPATIBILITY; MICROENVIRONMENT; EFFECTOR; EPIDEMIOLOGY; SECRETOME; INVASION;
D O I
10.1007/s00262-015-1788-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Spread of head and neck cancer along the cranial nerves is often a lethal complication of this tumour. Current treatment options include surgical resection and/or radiotherapy, but recurrence is a frequent event suggesting that our understanding of this tumour and its microenvironment is incomplete. In this study, we have analysed the nature of the perineural tumour microenvironment by immunohistochemistry with particular focus on immune cells and molecules, which might impair anti-tumour immunity. Moderate to marked lymphocyte infiltrates were present in 58.8 % of the patient cohort including T cells, B cells and FoxP3-expressing T cells. While human leukocyte antigen (HLA) class I and more variably HLA class II were expressed on the tumour cells, this did not associate with patient survival or recurrence. In contrast, galectin-1 staining within lymphocyte areas of the tumour was significantly associated with a poorer patient outcome. Given the known role of galectin-1 in immune suppression, the data suggest that galectin inhibitors might improve the prognosis of patients with perineural spread of cancer.
引用
收藏
页码:213 / 222
页数:10
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