Cerebellar transcranial direct current stimulation in children with ataxic cerebral palsy: A sham-controlled, crossover, pilot study

被引：44

作者：

Collange Grecco, Luanda Andre ^{[1
,2
,3
]}

Oliveira, Claudia Santos ^{[1
]}

Carvalho Duarte, Natalia de Almeida ^{[1
]}

Carvalho Lima, Vania L. C. ^{[4
]}

Zanon, Nelci ^{[2
]}

Fregni, Felipe ^{[3
]}

机构：

[1] Univ Nove Julho, Postgrad Rehabil Sci, Sao Paulo, SP, Brazil

[2] Ctr CENEPE, Pediat Neurosurg, Sao Paulo, SP, Brazil

[3] Harvard Med Sch, Spaulding Rehabil Hosp, Spaulding Neuromodulat Ctr, Dept Phys Med & Rehabil, Boston, MA USA

[4] Univ Fed Sao Paulo, Commun Disorders Dept, Sao Paulo, SP, Brazil

来源：

DEVELOPMENTAL NEUROREHABILITATION | 2017年 / 20卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Ataxic; balance; cerebral palsy; children; transcranial direct current stimulation; MOTOR CORTEX; ADAPTATION;

D O I：

10.3109/17518423.2016.1139639

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The aim of the present study was to analyze the use of anodal tDCS of the cerebellar region combined with treadmill training to improve balance and functional performance in children with ataxic cerebral palsy. Design: Single-blind, sham-controlled, crossover, pilot study. Setting: Rehabilitation center and research motion analysis laboratory. Participants: Children (N = 6) with ataxic cerebral palsy and balance deficit. Main Outcome Measures: Static balance (oscillations of the center of pressure), functional balance (Pediatric Balance Scale) and functional performance (Pediatric Evaluation of Disability Inventory) were evaluated. Results: Significant reductions occurred in oscillations of the center of pressure with eyes closed after active anodal tDCS only. The effects of treadmill training on functional balance and functional performance in mobility were maintained in the active tDCS group only. Conclusion: These preliminary data support the notion that anodal tDCS of the cerebellar region combined with treadmill training improves balance in children with ataxic cerebral palsy.

引用

页码：142 / 148

页数：7

共 25 条

[11]

Grimaldi G, 2014, NEUROSCIENTIST

[12] Anodal Transcranial Direct Current Stimulation (tDCS) Decreases the Amplitudes of Long-Latency Stretch Reflexes in Cerebellar Ataxia [J].

Grimaldi, Giuliana ;

Manto, Mario .

ANNALS OF BIOMEDICAL ENGINEERING, 2013, 41 (11) :2437-2447

[13]

Haley S., 1991, PEDIATR PHYS THER, V3, P177

[14]

ILOEJE SO, 1992, E AFR MED J, V69, P58

[15] Modulating locomotor adaptation with cerebellar stimulation [J].

Jayaram, Gowri ;

Tang, Byron ;

Pallegadda, Rani ;

Vasudevan, Erin V. L. ;

Celnik, Pablo ;

Bastian, Amy .

JOURNAL OF NEUROPHYSIOLOGY, 2012, 107 (11) :2950-2957

[16] A gene for ataxic cerebral palsy maps to chromosome 9p12-q12 [J].

McHale, DP ;

Jackson, AP ;

Campbell, DA ;

Levene, MI ;

Corry, P ;

Woods, CG ;

Lench, NJ ;

Mueller, RF ;

Markham, AF .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2000, 8 (04) :267-272

[17] Prevalence of ataxia in children A systematic review [J].

Musselman, Kristin E. ;

Stoyanov, Cristina T. ;

Marasigan, Rhul ;

Jenkins, Mary E. ;

Konczak, Juergen ;

Morton, Susanne M. ;

Bastian, Amy J. .

NEUROLOGY, 2014, 82 (01) :80-89

[18]

NASHNER LM, 1982, J NEUROSCI, V2, P536

[19]

NdAC Duarte, 2014, EFFECT TRANSCRANIAL, V9

[20]

NdAC Duarte, 2014, PLOS ONE, V9

← 1 2 3 →