Copper-Catalyzed Remote para-C-H Functionalization of Anilines with Sodium and Lithium Sulfinates

被引：88

作者：

Liang, Shuai ^{[1
]}

Bolte, Michael ^{[2
]}

Manolikakes, Georg ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, Max von Laue Str 7, D-60438 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Inst Inorgan & Analyt Chem, Max von Laue Str 7, D-60438 Frankfurt, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 01期

关键词：

C-H functionalization; copper; manganese; site-selectivity; sulfone; QUINOLINE N-OXIDES; SULFUR-DIOXIDE; ACID SALTS; BOND FUNCTIONALIZATION; ARYLSULFONYL CHLORIDES; SULFONE SYNTHESIS; C(SP(2))-H BONDS; DIARYL SULFONES; ARYL SULFONES; BORONIC ACIDS;

D O I：

10.1002/chem.201605101

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed, cross-dehydrogenative coupling of anilines with sodium and lithium sulfinates was developed. By using a cooperative reaction system with Mn(OAc)(3) as stoichiometric co-oxidant a highly selective para-functionalization of anilines was accomplished. Various functional groups were tolerated and the desired products were obtained in high yields. This method not only provides a novel approach for the synthesis of arylsulfones but might also offer new opportunities for the development of copper-catalyzed para-selective C-H functionalizations.

引用

页码：96 / 100

页数：5

共 58 条

[1] C-H ACTIVATION Following directions [J].