Marked decrease of plasma neuroactive steroids during alcohol withdrawal

被引:84
作者
Romeo, E
Brancati, A
DeLorenzo, A
Fucci, P
Furnari, C
Pompili, E
Sasso, GF
Spalletta, G
Troisi, A
Pasini, A
机构
[1] UNIV ROMA TOR VERGATA,DEPT PSYCHIAT,I-00193 ROME,ITALY
[2] UNIV ROMA TOR VERGATA,DEPT LEGAL MED,I-00193 ROME,ITALY
[3] UNIV ROMA LA SAPIENZA,CTR ALCOHOL ABUSE,ROME,ITALY
关键词
steroids; alcohol; withdrawal; anxiety; depression;
D O I
10.1097/00002826-199619040-00011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The neuroactive steroids allopregnanolone (ALLO) and allotetrahydrodeoxycorticosterone (THDOC) are the most potent endogenous positive modulators of gamma-aminobutyric acid (GABA) on GABA(A) receptors, a receptor system presumably responsible for some behavioral responses to alcohol withdrawal. In a group of nine alcoholic subjects, the levels of plasma ALLO and THDOC were markedly lower than those of control subjects during the early withdrawal phase (day 4 and 5), when anxiety and depression scores were higher. In contrast ALLO and THDOC plasma levels did not differ from those of control subjects during the late withdrawal phase when anxiety and depression scores were low. These results suggest that the decrease of neuroactive steroid biosynthesis may contribute to the withdrawal symptoms.
引用
收藏
页码:366 / 369
页数:4
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