Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia

被引：49

作者：

Catrina, Sergiu-Bogdan ^{[1
,2
]}

机构：

[1] Karolinska Univ Hosp, Rolf Luft Res Ctr Diabet & Endocrinol, Karolinska Inst, Dept Mol Med & Surg, S-17176 Stockholm, Sweden

[2] Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, S-17176 Stockholm, Sweden

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2014年 / 92卷 / 10期

基金：

瑞典研究理事会;

关键词：

Hypoxia-inducible factor; Hyperglycaemia; Diabetes; Chronic complications; Pathogenic mechanisms; ENDOTHELIAL GROWTH-FACTOR; ALTERED GENE-EXPRESSION; GLYCATION END-PRODUCTS; PANCREATIC BETA-CELL; DIET-INDUCED OBESITY; DIABETIC MICE; FACTOR-I; MYOCARDIAL-INFARCTION; SKELETAL-MUSCLE; FACTOR; 1-ALPHA;

D O I：

10.1007/s00109-014-1166-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mechanisms that contribute to the development of diabetes complications remain unclear. A defective reaction of tissues to hypoxia has recently emerged as a new pathogenic mechanism and consists of a complex repression of hypoxia-inducible factor (HIF), which is the main regulator of the adaptive response to hypoxia. This paper discusses the mechanisms by which hyperglycaemia contributes to HIF repression in diabetes. Furthermore, a comprehensive analysis of the functional relevance of these new findings to the development of chronic diabetes complications is provided, along with examples from animal models and clinics.

引用

页码：1025 / 1034

页数：10

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