Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia

被引：49

作者：

Catrina, Sergiu-Bogdan ^{[1
,2
]}

机构：

[1] Karolinska Univ Hosp, Rolf Luft Res Ctr Diabet & Endocrinol, Karolinska Inst, Dept Mol Med & Surg, S-17176 Stockholm, Sweden

[2] Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, S-17176 Stockholm, Sweden

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2014年 / 92卷 / 10期

基金：

瑞典研究理事会;

关键词：

Hypoxia-inducible factor; Hyperglycaemia; Diabetes; Chronic complications; Pathogenic mechanisms; ENDOTHELIAL GROWTH-FACTOR; ALTERED GENE-EXPRESSION; GLYCATION END-PRODUCTS; PANCREATIC BETA-CELL; DIET-INDUCED OBESITY; DIABETIC MICE; FACTOR-I; MYOCARDIAL-INFARCTION; SKELETAL-MUSCLE; FACTOR; 1-ALPHA;

D O I：

10.1007/s00109-014-1166-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mechanisms that contribute to the development of diabetes complications remain unclear. A defective reaction of tissues to hypoxia has recently emerged as a new pathogenic mechanism and consists of a complex repression of hypoxia-inducible factor (HIF), which is the main regulator of the adaptive response to hypoxia. This paper discusses the mechanisms by which hyperglycaemia contributes to HIF repression in diabetes. Furthermore, a comprehensive analysis of the functional relevance of these new findings to the development of chronic diabetes complications is provided, along with examples from animal models and clinics.

引用

收藏

页码：1025 / 1034

页数：10

相关论文

共 98 条

[1] VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].

AIELLO, LP ;

AVERY, RL ;

ARRIGG, PG ;

KEYT, BA ;

JAMPEL, HD ;

SHAH, ST ;

PASQUALE, LR ;

THIEME, H ;

IWAMOTO, MA ;

PARK, JE ;

NGUYEN, HV ;

AIELLO, LM ;

FERRARA, N ;

KING, GL .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1480-1487

[2] Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice [J].

Amin, Ali H. ;

Abd Elmageed, Zakaria Y. ;

Nair, Devika ;

Partyka, Megan I. ;

Kadowitz, Philip J. ;

Belmadani, Souad ;

Matrougui, Khalid .

LABORATORY INVESTIGATION, 2010, 90 (07) :985-996

[3] The pathogenesis of early retinal changes of diabetic retinopathy [J].

Arden, G. B. ;

Sivaprasad, S. .

DOCUMENTA OPHTHALMOLOGICA, 2012, 124 (01) :15-26

[4] Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction [J].

Bento, C. F. ;

Fernandes, R. ;

Matafome, P. ;

Sena, C. ;

Seica, R. ;

Pereira, P. .

EXPERIMENTAL PHYSIOLOGY, 2010, 95 (09) :955-970

[5] The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal [J].

Bento, Carla Figueira ;

Fernandes, Rosa ;

Ramalho, Jose ;

Marques, Carla ;

Shang, Fu ;

Taylor, Allen ;

Pereira, Paulo .

PLOS ONE, 2010, 5 (11)

[6] Stabilization of HIF-1α is critical to improve wound healing in diabetic mice [J].

Botusan, Ileana Ruxandra ;

Sunkari, Vivekananda Gupta ;

Savu, Octavian ;

Catrina, Anca Irinel ;

Grunler, Jacob ;

Lindberg, Stina ;

Pereira, Teresa ;

Yla-Herttuala, Seppo ;

Poellinger, Lorenz ;

Brismar, Kerstin ;

Catrina, Sergiu-Bogdan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (49) :19426-19431

[7]

Bursell SE, 1996, INVEST OPHTH VIS SCI, V37, P886

[8] Deletion of the von Hippel-Lindau gene in pancreatic β cells impairs glucose homeostasis in mice [J].

Cantley, James ;

Selman, Colin ;

Shukla, Deepa ;

Abramov, Andrey Y. ;

Forstreuter, Frauke ;

Esteban, Miguel A. ;

Claret, Marc ;

Lingard, Steven J. ;

Clements, Melanie ;

Harten, Sarah K. ;

Asare-Anane, Henry ;

Batterham, Rachel L. ;

Herrera, Pedro L. ;

Persaud, Shanta J. ;

Duchen, Michael R. ;

Maxwell, Patrick H. ;

Withers, Dominic J. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) :125-135

[9] Hyperglycentia regulates hypoxia-inducible factor-1α protein stability and function [J].

Catrina, SB ;

Okamoto, K ;

Pereira, T ;

Brismar, K ;

Poellinger, L .

DIABETES, 2004, 53 (12) :3226-3232

[10] Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice [J].

Ceradini, Daniel J. ;

Yao, Dachun ;

Grogan, Raymon H. ;

Callaghan, Matthew J. ;

Edelstein, Diane ;

Brownlee, Michael ;

Gurtner, Geoffrey C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (16) :10930-10938

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