Role of Transforming Growth Factor- in Skeletal Muscle Fibrosis: A Review

被引：100

作者：

Ismaeel, Ahmed ^{[1
]}

Kim, Jeong-Su ^{[1
]}

Kirk, Jeffrey S. ^{[2
]}

Smith, Robert S. ^{[3
]}

Bohannon, William T. ^{[3
]}

Koutakis, Panagiotis ^{[1
]}

机构：

[1] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32304 USA

[2] Capital Reg Med Ctr, Dept Surg, Tallahassee, FL 32308 USA

[3] Baylor Scott & White Hosp, Dept Surg, Temple, TX 76508 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 10期

关键词：

TGF-; fibrosis; skeletal muscle; myopathy; TGF-BETA; MUSCULAR-DYSTROPHY; UP-REGULATION; EXPRESSION; MYOSTATIN; INHIBITION; TGF-BETA-1; MICE; TRANSCRIPTION; ACTIVATION;

D O I：

10.3390/ijms20102446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-beta (TGF-) isoforms are cytokines involved in a variety of cellular processes, including myofiber repair and regulation of connective tissue formation. Activation of the TGF- pathway contributes to pathologic fibrosis in most organs. Here, we have focused on examining the evidence demonstrating the involvement of TGF- in the fibrosis of skeletal muscle particularly. The TGF- pathway plays a role in different skeletal muscle myopathies, and TGF- signaling is highly induced in these diseases. In this review, we discuss different molecular mechanisms of TGF--mediated skeletal muscle fibrosis and highlight different TGF--targeted treatments that target these relevant pathways.

引用

页数：15

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