Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

被引：48

作者：

Gonzales, S. Jake ^{[1
]}

Reyes, Raphael A. ^{[1
]}

Braddom, Ashley E. ^{[1
]}

Batugedara, Gayani ^{[1
]}

Bol, Sebastiaan ^{[1
]}

Bunnik, Evelien M. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Long Sch Med, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

美国国家卫生研究院;

关键词：

antibody; protection; variant surface antigens; PfEMP1; merozoite; vaccine; MEMORY B-CELLS; ERYTHROCYTE-MEMBRANE PROTEIN-1; MEROZOITE ANTIGENS; INFECTED ERYTHROCYTES; STEVOR PROTEINS; BINDING PFEMP1; GENE FAMILY; ANTIBODIES; RECEPTOR; PROTECTION;

D O I：

10.3389/fimmu.2020.594653

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria remains a significant contributor to the global burden of disease, with around 40% of the world's population at risk of Plasmodium infections. The development of an effective vaccine against the malaria parasite would mark a breakthrough in the fight to eradicate the disease. Over time, natural infection elicits a robust immune response against the blood stage of the parasite, providing protection against malaria. In recent years, we have gained valuable insight into the mechanisms by which IgG acts to prevent pathology and inhibit parasite replication, as well as the potential role of immunoglobulin M (IgM) in these processes. Here, we discuss recent advances in our understanding of the mechanisms, acquisition, and maintenance of naturally acquired immunity, and the relevance of these discoveries for the development of a potential vaccine against the blood stage of Plasmodium falciparum.

引用

页数：15

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