Bacteriophage Vehicles for Phage Display: Biology, Mechanism, and Application

被引:55
作者
Ebrahimizadeh, Walead [1 ]
Rajabibazl, Masoumeh [2 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran
关键词
ANTIBODY PHAGE; HELPER PHAGE; RECOMBINANT ANTIBODIES; EXPERIMENTAL EVOLUTION; DNA VACCINE; IN-VITRO; PROTEIN; LAMBDA; SELECTION; DISCOVERY;
D O I
10.1007/s00284-014-0557-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The phage display technique is a powerful tool for selection of various biological agents. This technique allows construction of large libraries from the antibody repertoire of different hosts and provides a fast and high-throughput selection method. Specific antibodies can be isolated based on distinctive characteristics from a library consisting of millions of members. These features made phage display technology preferred method for antibody selection and engineering. There are several phage display methods available and each has its unique merits and application. Selection of appropriate display technique requires basic knowledge of available methods and their mechanism. In this review, we describe different phage display techniques, available bacteriophage vehicles, and their mechanism.
引用
收藏
页码:109 / 120
页数:12
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