The association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer

被引：7
|
作者：
Xiong, Tianyuan [1 ]
Yang, Jiqiao [1 ]
Wang, Haichuan [1 ]
Wu, Fanyi [1 ]
Liu, Yang [1 ]
Xu, Rui [1 ]
Lv, Zi [1 ]
Xue, Pei [1 ]
Cao, Wen [1 ]
Zhang, Yonggang [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, West China Med Sch, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 04期
关键词：
XPD; Bladder cancer; Polymorphism; Meta-analysis; DNA-REPAIR GENES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; XRCC1; SMOKING; ERCC2;
D O I：
10.1007/s11033-014-3121-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case-control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95-1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02-1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case-control studies are needed to validate our results.
引用
收藏
页码：2629 / 2634
页数：6
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