Bilateral Testicular Germ Cell Tumors: A Case-Series From a UK-Based Tertiary Referral Center Over 19 Years

Bilateral testicular germ cell tumors (TGCTs) are a rare occurrence, with a frequency in this series of 1.4% of all testicular cancer cases. However, patients with a diagnosis of TGCT have a vastly increased risk of developing a second tumor compared with the a priori risk for a healthy individual to develop TGCT. Because of the low incidence, most knowledge and understanding of this disease comes from case series and reports; to our knowledge this is the largest series published from a United Kingdom center in recent years. Most bilateral TGCT are metachronous, with a small percentage (33%) synchronous. The first tumor can present at a wide range of ages (19-75 years), with median age of first presentation 29 years. For metachronous tumors, the median time to second tumor presentation was 6.1 years, indicating that longer follow-up might be indicated for detecting a second tumor. (C) 2018 Elsevier Inc. All rights reserved.