Macrolide resistance mechanisms and expression of phenotypes among Streptococcus pneumoniae circulating in Italy

被引：56

作者：

Marchese, A ^{[1
]}

Tonoli, E ^{[1
]}

Debbia, EA ^{[1
]}

Schito, GC ^{[1
]}

机构：

[1] Univ Genoa, Inst Microbiol, I-16132 Genoa, Italy

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 44卷 / 04期

关键词：

D O I：

10.1093/jac/44.4.461

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In Italy, macrolide-resistant pneumococci have been isolated at a rate increasing from 6% in 1993 to 31.7% in 1998. A collection of 161 erythromycin-resistant Streptococcus pneumoniae recovered between 1993 and 1997 has now been phenotypically and genotypically characterized. Approximately 90% of these microorganisms possessed a constitutive MLSB mechanism of resistance. PCR detected ermB and mefE genes in strains showing MLSB and M phenotypes, respectively. Using pulsed-field gel electrophoresis of chromosomal DNA, one dominant restriction profile and its variations were detected in 51 S. pneumoniae isolates collected from different locations, indicating the circulation of a clone characterized by the possession of a great ability to spread.

引用

页码：461 / 464

页数：4

共 11 条

[1] Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae [J].