Anticancer and Antimigration Effects of a Combinatorial Treatment of 5-Fluorouracil and Lactobacillus paracasei subsp paracasei NTU 101 Fermented Skim Milk Extracts on Colorectal Cancer Cells

被引：18

作者：

Chang, Chia-Yuan ^{[1
]}

Pan, Tzu-Ming ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Biochem Sci & Technol, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2018年 / 66卷 / 22期

关键词：

Lactobacillus paracasei subsp paracasei NTU 101; fermented skim milk extract; colorectal cancer; 5-fluorouracil; anticancer properties; LACTIC-ACID BACTERIA; IMMUNOMODULATING ACTIVITY; ANTITUMOR-ACTIVITY; GROWTH; HT-29; PROLIFERATION; OXALIPLATIN; METASTASIS; STRAINS; CARCINOMA;

D O I：

10.1021/acs.jafc.8b01445

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Metabolites of lactic acid bacteria (LAB) have anticancer and antimetastasis capacities. This study aimed to investigate the chemotherapeutic effects of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skim milk (NTU101-FM) extracts in combination with the chemotherapeutic drug 5-fluorouracil (5-FU) in a cellular CRC model. The NTU101-FM extracts effectively reduced CRC cell viability but were not cytotoxic to colon epithelial cells. Moreover, they increased RAW 264.7 cell viability. Notably, the cell viability of CRC cells was decreased by 5-FU in combination with the NTU101-FM extracts; the combinatorial treatment inhibited cell viability significantly more than 5-FU alone (p < 0.05). An ethanol extract of NTU101-FM effectively attenuated CT26 cell migration. In conclusion, the ethanol extract prepared from NTU101-FM has a potential application as an anticancer agent in CRC.

引用

页码：5549 / 5555

页数：7

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