Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target

被引：4

作者：

Bootsma, Sanne ^{[1
,2
,3
]}

van Neerven, Sanne M. ^{[1
,2
,3
]}

Vermeulen, Louis ^{[1
,2
,3
]}

机构：

[1] Canc Ctr Amsterdam, Ctr Expt & Mol Med, Lab Expt Oncol & Radiobiol, Amsterdam, Netherlands

[2] Amsterdam Univ Med Ctr, Amsterdam Gastroenterol & Metab, Amsterdam, Netherlands

[3] Oncode Inst Amsterdam, Amsterdam, Netherlands

来源：

NATURE GENETICS | 2021年 / 53卷 / 01期

关键词：

RAS;

D O I：

10.1038/s41588-020-00758-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Half of all colorectal cancers bear KRAS-activating mutations that affect the metabolic dependencies of cancer cells and drive resistance to commonly used drugs. A new study provides insights into KRAS-driven metabolic rewiring and identifies a new therapeutic target for KRAS-mutant cancers.

引用

页码：9 / 10

页数：2

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