Exploiting KRAS-mediated metabolic reprogramming as a therapeutic target

被引：3
作者：
Bootsma, Sanne [1 ,2 ,3 ]
van Neerven, Sanne M. [1 ,2 ,3 ]
Vermeulen, Louis [1 ,2 ,3 ]
机构：
[1] Canc Ctr Amsterdam, Ctr Expt & Mol Med, Lab Expt Oncol & Radiobiol, Amsterdam, Netherlands
[2] Amsterdam Univ Med Ctr, Amsterdam Gastroenterol & Metab, Amsterdam, Netherlands
[3] Oncode Inst Amsterdam, Amsterdam, Netherlands
来源：
NATURE GENETICS | 2021年 / 53卷 / 01期
关键词：
RAS;
D O I：
10.1038/s41588-020-00758-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Half of all colorectal cancers bear KRAS-activating mutations that affect the metabolic dependencies of cancer cells and drive resistance to commonly used drugs. A new study provides insights into KRAS-driven metabolic rewiring and identifies a new therapeutic target for KRAS-mutant cancers.
引用
收藏
页码：9 / 10
页数：2
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