Fourier X-ray Scattering Radiography Yields Bone Structural Information

被引:117
作者
Wen, Han [1 ]
Bennett, Eric E. [1 ]
Hegedus, Monica M. [2 ]
Rapacchi, Stanislas [3 ,4 ]
机构
[1] NHLBI, NIH, Bethesda, MD 20892 USA
[2] Thomas Jefferson Med Coll, Philadelphia, PA USA
[3] Ctr Rech & Applicat Traitement Image, Lyon, France
[4] Inst Natl Sci Appl Lyon, Signal Lab Resonance Magnet Nucl, Lyon, France
关键词
GRATING INTERFEROMETER; BREAST-CANCER; DIFFRACTION; MICROSCOPE; SPECTRA; CT;
D O I
10.1148/radiol.2521081903
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To characterize certain aspects of the microscopic structures of cortical and trabecular bone by using Fourier x-ray scattering imaging. Materials and Methods: Protocols approved by the National Institutes of Health Animal Care and Use Committee were used to examine ex vivo the hind limb of a rat and the toe of a pig. The Fourier x-ray scattering imaging technique involves the use of a grid mask to modulate the cone beam and Fourier spectral filters to isolate the harmonic images. The technique yields attenuation, scattering, and phase-contrast (PC) images from a single exposure. In the rat tibia cortical bone, the scattering signals from two orthogonal grid orientations were compared by using Wilcoxon signed rank tests. In the pig toe, the heterogeneity of scattering and PC signals was compared between trabecular and compact bone regions of uniform attenuation by using F tests. Results: In cortical bone, the scattering signal was significantly higher (P < 10(-15)) when the grid was parallel to the periosteal surface. Trabecular bone, as compared with cortical bone, appeared highly heterogeneous on the scattering (P < 10(-34)) and PC (P < 10(-27)) images. Conclusion: The ordered alignment of the mineralized collagen fibrils in compact bone was reflected in the anisotropic scattering signal in this bone. In trabecular bone, the porosity of the mineralized matrix accounted for the granular pattern seen on the scattering and PC images. (C) RSNA, 2009
引用
收藏
页码:910 / 918
页数:9
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