Large-scale Genotyping and Genetic Mapping in Plasmodium Parasites

被引：5

作者：

Su, Xin-zhuan ^{[1
]}

Jiang, Hongying ^{[1
]}

Yi, Ming ^{[2
]}

Mu, Jianbing ^{[1
]}

Stephens, Robert M. ^{[2
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA

来源：

KOREAN JOURNAL OF PARASITOLOGY | 2009年 / 47卷 / 02期

关键词：

Plasmodium; malaria; phenotype; genotype; microsatellite; SNP; HUMAN MALARIA PARASITE; SINGLE-NUCLEOTIDE POLYMORPHISMS; CHLOROQUINE-RESISTANCE LOCUS; MICROSATELLITE MARKERS; MEFLOQUINE RESISTANCE; FALCIPARUM INFECTIONS; COMPARATIVE GENOMICS; MIXED INFECTIONS; DRUG-RESISTANCE; MUTATIONS;

D O I：

10.3347/kjp.2009.47.2.83

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The completion of many malaria parasite genomes provides great opportunities for genomewide characterization of gene expression and high-throughput genotyping. Substantial progress in malaria genomics and genotyping has been made recently, particularly the development of various microarray platforms for large-scale characterization of the Plasmodium falciparum genome. Microarray has been used for gene expression analysis, detection of single nucleotide polymorphism ( SNP) and copy number variation (CNV), characterization of chromatin modifications, and other applications. Here we discuss some recent advances in genetic mapping and genomic studies of malaria parasites, focusing on the use of high-throughput arrays for the detection of SNP and CNV in the P. falciparum genome. Strategies for genetic mapping of malaria traits are also discussed.

引用

页码：83 / 91

页数：9

共 92 条

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