Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription

被引：32

作者：

Cai, XF ^{[1
]}

Lee, IS ^{[1
]}

Shen, G ^{[1
]}

Dat, NT ^{[1
]}

Lee, JJ ^{[1
]}

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 08期

关键词：

Acanthopanax koreanum; Araliaceae; triterpenoid; NFAT transcription factor; inhibitory effect;

D O I：

10.1007/BF02980173

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 muM).

引用

页码：825 / 828

页数：4

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