Strain-Promoted Oxidative Annulation of Arynes and Cyclooctynes with Benzamides: Palladium-Catalyzed C-H/N-H Activation for the Synthesis of N-Heterocycles

被引：92

作者：

Peng, Xianglong ^{[1
]}

Wang, Weiguo ^{[1
]}

Jiang, Chao ^{[1
]}

Sun, Di ^{[1
]}

Xu, Zhenghu ^{[1
]}

Tung, Chen-Ho ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Key Lab Colloid & Interface Chem, Educ Minist, Jinan 250100, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 20期

关键词：

FUSED POLYCYCLIC AROMATICS; HIGHLY EFFICIENT ROUTE; METAL RELAY CATALYSIS; MOLECULAR-OXYGEN; INDOLE SYNTHESIS; BORONIC ACIDS; ARYL HALIDES; DEHYDROGENATIVE ANNULATION; INTRAMOLECULAR AMINATION; ISOQUINOLONE SYNTHESIS;

D O I：

10.1021/ol5025426

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Strained alkynes include arynes and cyclooctynes reacted with N-methoxyamides through palladium-catalyzed C-H/N-H activation for the first time. A variety of important N-heterocycles such as phenanthridinones and isoquinolones were constructed in one step with high efficiency.

引用

页码：5354 / 5357

页数：4

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